ArticleParasitology research2010
Selection and phenotype characterization of potassium antimony tartrate-resistant populations of four New World Leishmania species.
Article in Parasitology research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Targeting p53 pathways: mechanisms, structures, and advances in therapy.Signal transduction and targeted therapy · 2023Pooled it
- Translational reprogramming as a driver of antimony-drug resistance in Leishmania.Nature communications · 2023Article
- In-Depth Quantitative Proteomics Characterization of In Vitro Selected Miltefosine Resistance inProteomes · 2022Article
- Downregulation of FeSOD-A expression in Leishmania infantum alters trivalent antimony and miltefosine susceptibility.Parasites & vectors · 2021Article
- A nanoemulsion-based nanogel ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Article
- Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines.Parasites & vectors · 2020Article
- Leishmania infantum induces high phagocytic capacity and intracellular nitric oxide production by human proinflammatory monocyte.Memorias do Instituto Oswaldo Cruz · 2020Article
- The heterologous expression of Escherichia coli MutT enzyme is involved in the protection against oxidative stress in Leishmania braziliensis.Memorias do Instituto Oswaldo Cruz · 2020Article
- Major changes in chromosomal somy, gene expression and gene dosage driven by SbScientific reports · 2019Article
- Mannosyltransferase (GPI-14) overexpression protects promastigote and amastigote forms of Leishmania braziliensis against trivalent antimony.Parasites & vectors · 2019Article
- 2'-Hydroxyflavanone activity in vitro and in vivo against wild-type and antimony-resistant Leishmania amazonensis.PLoS neglected tropical diseases · 2018Article
- Ascorbate peroxidase overexpression protects Leishmania braziliensis against trivalent antimony effects.Memorias do Instituto Oswaldo Cruz · 2018Article
- Involvement of nucleoside diphosphate kinase b and elongation factor 2 in Leishmania braziliensis antimony resistance phenotype.Parasites & vectors · 2016Article
- Disrupting ROS-protection mechanism allows hydrogen peroxide to accumulate and oxidize Sb(III) to Sb(V) in Pseudomonas stutzeri TS44.BMC microbiology · 2016Article
- Silver and Nitrate Oppositely Modulate Antimony Susceptibility through Aquaglyceroporin 1 in Leishmania (Viannia) Species.Antimicrobial agents and chemotherapy · 2016Article
- Functional analysis of cytosolic tryparedoxin peroxidase in antimony-resistant and -susceptible Leishmania braziliensis and Leishmania infantum lines.Parasites & vectors · 2014Article
- Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response.PLoS neglected tropical diseases · 2014Article
- Frequency of MDR1-related p-gp overexpression in Greek Leishmania isolates.Parasitology research · 2014Article
- Comparative analysis of the omics technologies used to study antimonial, amphotericin B, and pentamidine resistance in leishmania.Journal of parasitology research · 2014Review
- Molecular characterization of the MRPA transporter and antimony uptake in four New World Leishmania spp. susceptible and resistant to antimony.International journal for parasitology. Drugs and drug resistance · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, we selected in vitro populations of Leishmania Viannia guyanensis, L.V. braziliensis, L. Leishmania amazonensis and L.L. infantum chagasi that were resistant to potassium antimony tartrate (SbIII). The resistance index of these populations varied from 4- to 20-fold higher than that of their wild-type counterparts. To evaluate the stability of the resistance phenotype, these four resistant populations were passaged 37 to 47 times in a culture medium without SbIII. No change was observed in the resistance indexes of L.V. guyanensis (19-fold) and L.L. infantum chagasi (4-fold). In contrast, a decrease in the resistance index was observed for L.V. braziliensis (from 20- to 10-fold) and L.L. amazonensis (from 6- to 3-fold). None of the antimony-resistant populations exhibited cross-resistance to amphotericin B and miltefosine. However, the resistant populations of L.V. braziliensis, L.L. amazonensis and L.L. infantum chagasi were also resistant to paromomycin. A drastic reduction was observed in the infectivity in mice for the resistant L.V. guyanensis, L.L. amazonensis and L.V. braziliensis populations. The SbIII-resistant phenotype of L.V. braziliensis was stable after one passage in mice. Although the protocol of induction was the same, the SbIII-resistant populations showed different degrees of tolerance, stability, infectivity in mice and cross-resistance to antileishmanial drugs, depending on the Leishmania species.
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