Trial reportWorld journal of surgery2010
Effects of low central venous pressure during preanhepatic phase on blood loss and liver and renal function in liver transplantation.
Trial report in World journal of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022Pooled it
- Effectiveness and safety of controlled venous pressure in liver surgery: a systematic review and network meta-analysis.BioMed research international · 2015Pooled it
- Intraoperative phlebotomies and bleeding in liver transplantation: a historical cohort study and causal analysis.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022Trial
- Trial
- Relationship between Stroke Volume Variation and Blood Transfusion during Liver Transplantation.International journal of medical sciences · 2016Trial
- Prothrombin complex concentrate in the reduction of blood loss during orthotopic liver transplantation: PROTON-trial.BMC surgery · 2013Trial
- Effect of low central venous pressure on postoperative pulmonary complications in patients undergoing liver transplantation.Surgery today · 2013Trial
- Feasibility of using head up patient position in maintaining low central venous pressure and restricting the need for pharmacological agents during major hepatectomy.Annals of hepato-biliary-pancreatic surgery · 2026Article
- Anesthesia for the First Fully Robotic Simultaneous Living Donor Liver Transplant in Europe.Cureus · 2026Article
- Effects of Preanhepatic Glucose-Insulin Infusion on Metabolic and Hemodynamic Outcomes in Liver Transplantation: A Randomized Clinical Trial : Preanhepatic Glucose-Insulin Infusion and Liver Transplantation.Galen medical journal · 2025Article
- Four-factor Prothrombin Complex Concentrate During Liver Transplantation: A Retrospective Cohort Study.Transplantation direct · 2024Article
- An overview of unresolved issues in the perioperative management of liver transplant patients.Korean journal of transplantation · 2023Review
- Association of different central venous pressure levels with outcome of living-donor liver transplantation in children under 12 years.World journal of pediatrics : WJP · 2023Article
- Effect of cardiac output - guided hemodynamic management on acute lung injury in pediatric living donor liver transplantation.World journal of gastrointestinal surgery · 2022Article
- Intraoperative High Tidal Volume Ventilation and Postoperative Acute Respiratory Distress Syndrome in Liver Transplant.Transplantation proceedings · 2022Article
- Hemorrhagic Complications of Invasive Intracranial Pressure Monitor Placement in Acute Liver Failure: Outcomes of a Single-Center Protocol and Comprehensive Literature Review.Neurocritical care · 2021Article
- Effect of controlled low central venous pressure technique on postoperative hepatic insufficiency in patients undergoing a major hepatic resection.American journal of translational research · 2021Article
- Anaesthesia for Liver Transplantation: An Update.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2020Article
- Prediction of postoperative outcomes using intraoperative hemodynamic monitoring data.Scientific reports · 2017Article
- Liver transplantation in Jehovah's Witnesses: two cases report.Korean journal of anesthesiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the low central venous pressure (LCVP) technique is used to decrease blood loss during liver resection, its efficacy and safety during transplant procedures are still debatable. Our study aimed to assess the effects of this technique and its clinical safety for recipients undergoing liver transplantation.
methodsEighty-six adult patients were randomly divided into a LCVP group and a control group. In the LCVP group, CVP was maintained below 5 mmHg or 40% lower than baseline during the preanhepatic phase by limiting infusion volume, manipulating the patient's posture, and administration of somatostatin and nitroglycerine. Recipients in the control group received standard care. Hemodynamics, blood loss, liver function, and renal function of the two groups were compared perioperatively.
resultsA lower CVP was maintained in the LCVP group during the preanhepatic phase, resulting in a significant decrease in blood loss (1922 +/- 1429 vs. 3111 +/- 1833 ml, P < 0.05) and transfusion volume (1200 +/- 800 vs. 2400 +/- 1200 ml, P < 0.05) intraoperatively. Compared with the control group, the LCVP group had a significantly lower mean arterial pressure at 2 h after the start of the operation (74 +/- 11 vs. 84 +/- 14 mmHg, P < 0.05), a lower lactate value at the end of the operation (5.9 +/- 3.0 vs. 7.2 +/- 3.0 mmol/l, P < 0.05), and a better preservation of liver function after the declamping of the portal vein. There were no significant differences in perioperative renal function and postoperative complications between the groups.
conclusionsThe LCVP technique during the preanhepatic phase reduced intraoperative blood loss, protected liver function, and had no detrimental effects on renal function in LT.
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