ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Distinct functions of acj6 splice forms in odor receptor gene choice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 31 citations in OpenAlex.
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Identification of antennal alternative splicing by combining genome and full-length transcriptome analysis inFrontiers in physiology · 2024Article
- Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code.Neuron · 2022Article
- Olfactory Receptor Gene Regulation in Insects: Multiple Mechanisms for Singular Expression.Frontiers in neuroscience · 2021Review
- Single-Cell Transcriptomes Reveal Diverse Regulatory Strategies for Olfactory Receptor Expression and Axon Targeting.Current biology : CB · 2020Article
- Evolution, developmental expression and function of odorant receptors in insects.The Journal of experimental biology · 2020Review
- Linking neuronal lineage and wiring specificity.Neural development · 2018Review
- The Two Main Olfactory Receptor Families inFrontiers in cellular neuroscience · 2018Review
- Computational genome-wide survey of odorant receptors from two solitary bees Dufourea novaeangliae (Hymenoptera: Halictidae) and Habropoda laboriosa (Hymenoptera: Apidae).Scientific reports · 2017Article
- Transcriptional profiling of olfactory system development identifies distal antenna as a regulator of subset of neuronal fates.Scientific reports · 2017Article
- Dynamic expression of transcription factor Brn3b during mouse cranial nerve development.The Journal of comparative neurology · 2016Article
- A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity.PLoS genetics · 2016Article
- Drosophila Chemoreceptors: A Molecular Interface Between the Chemical World and the Brain.Trends in genetics : TIG · 2015Review
- Cis-regulatory mechanisms for robust olfactory sensory neuron class-restricted odorant receptor gene expression in Drosophila.PLoS genetics · 2015Article
- Combinatorial rules of precursor specification underlying olfactory neuron diversity.Current biology : CB · 2013Article
- Establishing and maintaining gene expression patterns: insights from sensory receptor patterning.Development (Cambridge, England) · 2013Review
- Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex.Genes & development · 2012Article
- Combinatorial expression of Brn3 transcription factors in somatosensory neurons: genetic and morphologic analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Sex-linked transcription factor involved in a shift of sex-pheromone preference in the silkmoth Bombyx mori.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Transcriptome profiling of chemosensory appendages in the malaria vector Anopheles gambiae reveals tissue- and sex-specific signatures of odor coding.BMC genomics · 2011Article
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2 authors at 1 institution in 1 country.
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Abstract
Individual olfactory receptor neurons (ORNs) selectively express one or a small number of odor receptors from among a large receptor repertoire. The expression of an odor receptor dictates the odor response spectrum of the ORN. The process of receptor gene choice relies in part on a combinatorial code of transcription factors. In Drosophila, the POU domain transcription factor Acj6 is one element of the transcription factor code. In acj6 null mutants, many ORNs do not express an appropriate odor receptor gene and thus are not correctly specified. We find that acj6 is alternatively spliced to yield many structurally distinct transcripts in the olfactory organs. We generate flies that express single splice forms of acj6 in an acj6(-) background. We find that different splice forms are functionally distinct; they differ in their abilities to specify ORN identities. Some individual splice forms can fully rescue the specification of some ORNs. Individual splice forms can function both positively and negatively in receptor gene regulation. ORNs differ in their requirements for splice forms; some are not fully rescued by any single splice form tested, suggesting that some ORNs may require the combinatorial action of multiple splice forms. Late expression of some acj6 splice forms is sufficient to rescue some ORN classes, consistent with a direct role for Acj6 isoforms in receptor gene expression. The results indicate that alternative splicing may add another level of richness to the regulatory code that underlies the process of odor receptor gene choice.
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