ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Early suppressive mechanisms and the negative blood oxygenation level-dependent response in human visual cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
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- Modafinil modulation of the default mode network.Psychopharmacology · 2011Trial
- BOLD response delays represent local cortical processing.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Investigating the Consistency of Negative BOLD Responses to Combinations of Visual, Auditory, and Somatosensory Stimuli and Their Modulation by the Level of Task Demand.Human brain mapping · 2025Article
- How does orientation-tuned normalization spread across the visual field?Journal of neurophysiology · 2025Article
- Temporal stability of the hemodynamic response function across the majority of human cerebral cortex.Human brain mapping · 2022Article
- Existence of Interhemispheric Inhibition between Foot Sections of Human Primary Motor Cortices: Evidence from Negative Blood Oxygenation-Level Dependent Signal.Brain sciences · 2021Article
- Retinotopic variations of the negative blood-oxygen-level dependent hemodynamic response function in human primary visual cortex.Journal of neurophysiology · 2021Article
- Importance of the Primary Motor Cortex in Development of Human Hand/Finger Dexterity.Cerebral cortex communications · 2020Article
- Dynamic metabolic changes in human visual cortex in regions with positive and negative blood oxygenation level-dependent response.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Asymmetries between achromatic and chromatic extraction of 3D motion signals.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Developmental Changes in Task-Induced Brain Deactivation in Humans Revealed by a Motor Task.Developmental neurobiology · 2019Article
- Article
- Positive and Negative Somatotopic BOLD Responses in Contralateral Versus Ipsilateral Penfield Homunculus.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Inverted optical intrinsic response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation.Scientific reports · 2016Article
- Normalization in human somatosensory cortex.Journal of neurophysiology · 2015Article
- Spatial specificity and inheritance of adaptation in human visual cortex.Journal of neurophysiology · 2015Article
- Functional magnetic resonance imaging adaptation reveals a noncategorical representation of hue in early visual cortex.Journal of vision · 2015Article
- On the role of suppression in spatial attention: evidence from negative BOLD in human subcortical and cortical structures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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2 authors at 2 institutions in 1 country.
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Abstract
Functional magnetic resonance imaging (fMRI) studies of early sensory cortex often measure stimulus-driven increases in the blood oxygenation level-dependent (BOLD) signal. However, these positive responses are frequently accompanied by reductions in the BOLD signal in adjacent regions of cortex. Although this negative BOLD response (NBR) is thought to result from neuronal suppression, the precise relationship between local activity, suppression, and perception remains unknown. By measuring BOLD signals in human primary visual cortex while varying the baseline contrast levels in the region affected by the NBR, we tested three physiologically plausible computational models of neuronal modulation that could explain this phenomenon: a subtractive model, a response gain model, and a contrast gain model. We also measured the ability of isoluminant contrast to generate an NBR. We show that the NBR can be modeled as a pathway-specific contrast gain modulation that is strongest outside the fovea. We found a similar spatial bias in a psychophysical study using identical stimuli, although these data indicated a response gain rather than a contrast gain mechanism. We reconcile these findings by proposing (1) that the NBR is associated with a long-range suppressive mechanism that hyperpolarizes a subset of magnocellularly driven neurons at the input to V1, (2) that this suppression is broadly tuned to match the spatial features of the mask region, and (3) that increasing the baseline contrast in the suppressed region drives all neurons in the input layer, reducing the relative contribution of the suppressing subpopulation in the fMRI signal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.