ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors.European journal of medicinal chemistry · 2022Article
- Skeletal Muscle Regeneration in Cardiotoxin-Induced Muscle Injury Models.International journal of molecular sciences · 2022Review
- MEK-inhibitor-mediated rescue of skeletal myopathy caused by activating Hras mutation in a Costello syndrome mouse model.Disease models & mechanisms · 2022Article
- p38 MAPKs - roles in skeletal muscle physiology, disease mechanisms, and as potential therapeutic targets.JCI insight · 2021Review
- An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.Science signaling · 2020Article
- Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.Scientific reports · 2020Article
- Improving Obesity and Insulin Resistance by Targeting Skeletal Muscle MKP-1.Journal of cellular signaling · 2020Article
- The paradox of metabolism in quiescent stem cells.FEBS letters · 2019Review
- Dual-specificity MAP kinase phosphatases in health and disease.Biochimica et biophysica acta. Molecular cell research · 2019Review
- RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes.PLoS genetics · 2018Article
- A Phosphoproteomic Screen Identifies a Guanine Nucleotide Exchange Factor for Rab3A Protein as a Mitogen-activated Protein (MAP) Kinase Phosphatase-5-regulated MAP Kinase Target in Interleukin 6 (IL-6) Secretion and Myogenesis.The Journal of biological chemistry · 2017Article
- Regulatory Roles of MAPK Phosphatases in Cancer.Immune network · 2016Review
- Mice lacking MKP-1 and MKP-5 Reveal Hierarchical Regulation of Regenerative Myogenesis.Journal of stem cell and regenerative biology · 2015Article
- Ex Vivo Expansion and In Vivo Self-Renewal of Human Muscle Stem Cells.Stem cell reports · 2015Article
- P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism.Human molecular genetics · 2014Article
- Altered macrophage phenotype transition impairs skeletal muscle regeneration.The American journal of pathology · 2014Article
- Shared signaling systems in myeloid cell-mediated muscle regeneration.Development (Cambridge, England) · 2014Review
- Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5.The Journal of clinical investigation · 2013Article
- Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.Human molecular genetics · 2013Article
- Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.Molecular and cellular biology · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
In skeletal muscle, the mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a critical negative regulator of the MAPKs. Since the MAPKs have been reported to be both positive and negative for myogenesis, the physiological role of MKP-1 in skeletal muscle repair and regeneration has remained unclear. Here, we show that MKP-1 plays an essential role in adult regenerative myogenesis. In a cardiotoxin-induced muscle injury model, lack of MKP-1 impaired muscle regeneration. In mdx mice, MKP-1 deficiency reduced body weight, muscle mass, and muscle fiber cross-sectional area. In addition, MKP-1-deficient muscles exhibit exacerbated myopathy accompanied by increased inflammation. Lack of MKP-1 compromised myoblast proliferation and induced precocious differentiation, phenotypes that were rescued by pharmacological inhibition of p38alpha/beta MAPK. MKP-1 coordinates both myoblast proliferation and differentiation. Mechanistically, MyoD bound to the MKP-1 promoter and activated MKP-1 expression in proliferating myoblasts. Later, during myogenesis, MyoD uncoupled from the MKP-1 promoter leading to the down-regulation of MKP-1 and facilitation of promyogenic p38alpha/beta MAPK signaling. Hence, MKP-1 plays a critical role in muscle stem cells and in the immune response to coordinate muscle repair and regeneration.
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Registered trials
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