ArticleScience translational medicine2010
The origins of sexually transmitted HIV among men who have sex with men.
Article in Science translational medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed.
- Article
- The importance of semen leukocytes in HIV-1 transmission and the development of prevention strategies.Human vaccines & immunotherapeutics · 2020Review
- No Evidence of SARS-CoV-2 Seminal Shedding Despite SARS-CoV-2 Persistence in the Upper Respiratory Tract.Open forum infectious diseases · 2020Article
- Compartmentalization and Clonal Amplification of HIV-1 in the Male Genital Tract Characterized Using Next-Generation Sequencing.Journal of virology · 2020Article
- Comparisons of Human Immunodeficiency Virus Type 1 Envelope Variants in Blood and Genital Fluids near the Time of Male-to-Female Transmission.Journal of virology · 2019Article
- Proliferative memory SAMHD1low CD4+ T cells harbour high levels of HIV-1 with compartmentalized viral populations.PLoS pathogens · 2019Article
- Article
- Review
- Environmental Stability and Infectivity of Hepatitis C Virus (HCV) in Different Human Body Fluids.Frontiers in microbiology · 2018Article
- No Substantial Evidence for Sexual Transmission of Minority HIV Drug Resistance Mutations in Men Who Have Sex with Men.Journal of virology · 2017Article
- The HIV-1 transmission bottleneck.Retrovirology · 2017Article
- Longitudinal Viral Dynamics in Semen During Early HIV Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- HIV Trafficking Between Blood and Semen During Early Untreated HIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Article
- HIV migration between blood plasma and cellular subsets before and after HIV therapy.Journal of medical virology · 2016Article
- Shedding of Hepatitis C Virus in Semen of Human Immunodeficiency Virus-Infected Men.Open forum infectious diseases · 2016Article
- Characterizing the multiplicity of HIV founder variants during sexual transmission among MSM.Virus evolution · 2016Article
- HIV transmission biology: translation for HIV prevention.AIDS (London, England) · 2015Review
- Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy.Scientific reports · 2015Article
- Seminal Shedding of CMV and HIV Transmission among Men Who Have Sex with Men.International journal of environmental research and public health · 2015Article
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Authors and funding
8 authors.
Funding
Abstract
Although it is known that most HIV-1 infections worldwide result from exposure to virus in semen, it has not yet been established whether transmitted strains originate as RNA virions in seminal plasma or as integrated proviral DNA in infected seminal leukocytes. We present phylogenetic evidence that among six transmitting pairs of men who have sex with men, blood plasma virus in the recipient is consistently more closely related to the seminal plasma virus in the source. All sequences were subtype B, and the env C2V3 of transmitted variants tended to have higher mean isoelectric points, contain potential N-linked glycosylation sites, and favor CCR5 co-receptor usage. A statistically robust phylogenetically corrected analysis did not detect genetic signatures reliably associated with transmission, but further investigation of larger samples of transmitting pairs holds promise for determining which structural and genetic features of viral genomes are associated with transmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.