Evidence map›Paper›PMID 20370911›Full record

ArticleGenome biology2010

miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data.

David Hendrix, Michael Levine, Weiyang Shi

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. Article
  3. An Integrated Bioinformatics and Functional Approach for miRNA Validation.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Predicting Drosha and Dicer Cleavage Sites with DeepMirCut.Frontiers in molecular biosciences · 2021
    Article
  9. Exploring miR-9 Involvement inInternational journal of molecular sciences · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Chickspress: a resource for chicken gene expression.Database : the journal of biological databases and curation · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

David HendrixDepartment of Molecular and Cell Biology, Division of Genetics, Genomics and Development, Center for Integrative Genomics, University of California, Berkeley, 142 LSA#3200, Berkeley, CA 94720-3200, USA. davidhendrix@berkeley.edu
Michael Levine
Weiyang Shi
University of California, Berkeley · USInnovative Genomics Institute · US

Funding

MOLECULAR CHARACTERIZATION OF THE DORSAL MORPHOGENR37GM046638 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI LEVINE, MICHAEL STEVEN · 2003 to 2012
$3.8M
Ascidian Stock Center (ASC)R24GM075049 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SMITH, WILLIAM · 2006 to 2009
$1.3M
NIGMS NIH HHS 5R24GM075049-04NIGMS NIH HHS R37 GM046638
6 · The paper itself

Abstract

MicroRNAs (miRs) have been broadly implicated in animal development and disease. We developed a novel computational strategy for the systematic, whole-genome identification of miRs from high throughput sequencing information. This method, miRTRAP, incorporates the mechanisms of miR biogenesis and includes additional criteria regarding the prevalence and quality of small RNAs arising from the antisense strand and neighboring loci. This program was applied to the simple chordate Ciona intestinalis and identified nearly 400 putative miR loci.

Indexed as

AnimalsBase SequenceCiona intestinalisComputational BiologyGenomeHigh-Throughput Screening AssaysMicroRNAsMolecular Sequence DataPhylogenySequence Analysis, RNAMicroRNAs

Identifiers

PMID20370911
PMCPMC2884542
OpenAlexW2055981636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.