ArticleAcademic emergency medicine : official journal of the Society for Academic Emergency Medicine2010
Complement activation in emergency department patients with severe sepsis.
Article in Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Sodium-glucose cotransporter-2 inhibitors and sepsis: a story with two tails or with one tail?Inflammopharmacology · 2026Review
- Hyper-inflammation and immunosuppression: redefining sepsis therapy using modern approaches.Frontiers in pharmacology · 2026Review
- Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis of health insurance claims in Japan.Frontiers in immunology · 2025Article
- Unraveling the Intricate Web: Complement Activation Shapes the Pathogenesis of Sepsis-Induced Coagulopathy.Journal of innate immunity · 2024Review
- Increase in the Complement Activation Product C4d and the Terminal Complement Complex sC5b-9 Is Associated with Disease Severity and a Fatal Outcome in Necrotizing Soft-Tissue Infection.Journal of innate immunity · 2022Article
- SARS-CoV-2: Pathogenic Mechanisms and Host Immune Response.Advances in experimental medicine and biology · 2021Article
- Elevated Serum C1q Levels in Children With Sepsis.Frontiers in pediatrics · 2021Article
- Complement levels in patients with bloodstream infection due to Staphylococcus aureus or Gram-negative bacteria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma.Bioconjugate chemistry · 2018Article
- Article
- Properdin levels in human sepsis.Frontiers in immunology · 2015Article
- Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Complement c5a generation by staphylococcal biofilms.Shock (Augusta, Ga.) · 2013Article
- Spatiotemporal dynamics of complement C5a production within bacterial extracellular polymeric substance.Journal of innate immunity · 2013Article
- The effect of human complement C3 protein applied at different times in treatment of polymicrobial sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Complement depletion deteriorates clinical outcomes of severe abdominal sepsis: a conspirator of infection and coagulopathy in crime?PloS one · 2012Article
- Interactions between coagulation and complement--their role in inflammation.Seminars in immunopathology · 2012Review
- Dynamics of human complement-mediated killing of Klebsiella pneumoniae.American journal of respiratory cell and molecular biology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThis study assessed the extent and mechanism of complement activation in community-acquired sepsis at presentation to the emergency department (ED) and following 24 hours of quantitative resuscitation.
methodsA prospective pilot study of patients with severe sepsis and healthy controls was conducted among individuals presenting to a tertiary care ED. Resuscitation, including antibiotics and therapies to normalize central venous and mean arterial pressure (MAP) and central venous oxygenation, was performed on all patients. Serum levels of Factor Bb (alternative pathway), C4d (classical and mannose-binding lectin [MBL] pathway), C3, C3a, and C5a were determined at presentation and 24 hours later among patients.
resultsTwenty patients and 10 healthy volunteer controls were enrolled. Compared to volunteers, all proteins measured were abnormally higher among septic patients (C4d 3.5-fold; Factor Bb 6.1-fold; C3 0.8-fold; C3a 11.6-fold; C5a 1.8-fold). Elevations in C5a were most strongly correlated with alternative pathway activation. Surprisingly, a slight but significant inverse relationship between illness severity (by sequential organ failure assessment [SOFA] score) and C5a levels at presentation was noted. Twenty-four hours of structured resuscitation did not, on average, affect any of the mediators studied.
conclusionsPatients with community-acquired sepsis have extensive complement activation, particularly of the alternative pathway, at the time of presentation that was not significantly reversed by 24 hours of aggressive resuscitation.
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Registered trials
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