ArticleJournal of gastroenterology and hepatology2010
CCl4-induced hepatic injury in mice fed a Western diet is associated with blunted healing.
Article in Journal of gastroenterology and hepatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency.bioRxiv : the preprint server for biology · 2026Article
- Protective effects of Longhu Rendan on chronic liver injury and fibrosis in mice.Liver research (Beijing, China) · 2022Article
- Impaired liver regeneration and lipid homeostasis in CClLaboratory animal research · 2020Article
- Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Interaction of volatile organic compounds and underlying liver disease: a new paradigm for risk.Biological chemistry · 2018Review
- Regulation of peroxisome proliferator-activated receptor gamma on milk fat synthesis in dairy cow mammary epithelial cells.In vitro cellular & developmental biology. Animal · 2016Article
- Role of activin A in carbon tetrachloride-induced acute liver injury.World journal of gastroenterology · 2013Article
- Thioacetamide-induced Hepatocellular Necrosis Is Attenuated in Diet-induced Obese Mice.Journal of toxicologic pathology · 2013Article
- Toxicant-associated steatohepatitis.Toxicologic pathology · 2013Review
- Fatty acids regulate endothelial lipase and inflammatory markers in macrophages and in mouse aorta: a role for PPARγ.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis.BMC gastroenterology · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsFeeding a Western diet (WD) enriched in saturated fat protects against chronic alcoholic hepatitis. However, saturated fat induces lipotoxicity in cultured hepatocytes. The purpose of the present study was to elucidate the influence of WD on acute hepatic injury and healing.
methodsMale C57BL/6 mice were fed a purified control diet (CD) or WD enriched in palmitate and cholesterol. After 3 weeks, carbon tetrachloride (CCl(4)) was administered (0.1 microL/g, intraperitoneally). Hepatic inflammation and proliferation were assessed by immunostaining for neutrophils and intracellular adhesion molecule-1, and Ki67, respectively. Cytokine expression was analyzed by real-time polymerase chain reaction. Protein levels of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) were assessed by western blotting.
resultsFeeding a WD resulted in markedly greater histological evidence of necrosis and enhanced alanine aminotransferase activity (188 +/- 6.2 U/L) compared to CD-fed mice (99.1 +/- 6.3 U/L) by day 2 post-CCl(4). In contrast, WD blunted leukocyte accumulation in necrotic areas and the expression of cytokines (tumor necrosis factor-alpha and interleukin-6) involved in tissue regeneration. Diminished repair was further indexed by lower collagen-alphaI and Ki67 expression in the mice fed a WD. Finally, feeding a WD, as well as the treatment of cultured hepatocytes with palmitic acid, upregulated the expression of PPAR-gamma, which has been previously shown to prevent hepatic repair following CCl(4) exposure.
conclusionsThese findings suggest that impaired healing in WD-fed mice blunted recovery from acute injury and underscored the complex relationship between diet and hepatic injury.
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