Evidence map›Paper›PMID 20369316›Full record

ReviewCurrent topics in microbiology and immunology2010

Simian varicella virus: molecular virology.

Wayne L Gray

Abstract readReview
In one paragraph

Review in Current topics in microbiology and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Simian Varicella Virus: Molecular Virology and Mechanisms of Pathogenesis.Current topics in microbiology and immunology · 2023
    Article
  5. Review
  6. Insights into the pathogenesis of varicella viruses.Current clinical microbiology reports · 2019
    Article
  7. Review
  8. Herpes zoster and the search for an effective vaccine.Clinical and experimental immunology · 2017
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Animal models of varicella zoster virus infection.Pathogens (Basel, Switzerland) · 2013
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Wayne L GrayDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. graywaynel@uams.edu
University of Arkansas for Medical Sciences · US

Funding

Animal models to design &evaluate improved VZV vaccinesR01AI052373 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI GRAY, WAYNE L · 2003 to 2007
$1.5M
NIAID NIH HHS R01 AI052373
6 · The paper itself

Abstract

Simian varicella virus (SVV) is a primate herpesvirus that is closely related to varicella-zoster virus (VZV), the causative agent of varicella (chickenpox) and herpes zoster (shingles). Epizootics of simian varicella occur sporadically in facilities housing Old World monkeys. This review summarizes the molecular properties of SVV. The SVV and VZV genomes are similar in size, structure, and gene arrangement. The 124.5 kilobase pair (kbp) SVV genome includes a 104.7 kbp long component covalently linked to a short component, which includes a 4.9 kbp unique short segment flanked by 7.5 kbp inverted repeat sequences. SVV DNA encodes 69 distinct open reading frames, three of which are duplicated within the viral inverted repeats. The viral genome is coordinately expressed, and immediate early (IE), early, and late genes have been characterized. Genetic approaches have been developed to create SVV mutants, which will be used to study the role of SVV genes in viral pathogenesis, latency, and reactivation. In addition, SVV expressing foreign genes are being investigated as potential recombinant varicella vaccines.

Indexed as

CercopithecidaeAnimalsDNA, ViralGene Expression Regulation, ViralGenome, ViralHerpesviridae InfectionsMonkey DiseasesMutagenesis, Site-DirectedOpen Reading FramesVaricellovirusDNA, Viral

Identifiers

PMID20369316
PMCPMC3269899
OpenAlexW78352318

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.