ArticleNeurochemical research2010
Increased reactive oxygen species production in the brain after repeated low-dose pesticide paraquat exposure in rats. A comparison with peripheral tissues.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- LRRK2-mediated mitochondrial dysfunction in Parkinson's disease.The Biochemical journal · 2025Review
- Diquat poisoning, maybe another cause of osmotic demyelination syndrome: case report and literature review.Frontiers in medicine · 2025Article
- Imaging Findings and Toxicological Mechanisms of Nervous System Injury Caused by Diquat.Molecular neurobiology · 2024Review
- Towards improved screening of toxins for Parkinson's risk.NPJ Parkinson's disease · 2023Review
- The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.Pharmacological reports : PR · 2022Article
- Roles of VGLUT2 and Dopamine/Glutamate Co-Transmission in Selective Vulnerability to Dopamine Neurodegeneration.ACS chemical neuroscience · 2022Review
- The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson's Disease.Cells · 2021Review
- Mendelian and Sporadic FTD: Disease Risk and Avenues from Genetics to Disease Pathways Through In Silico Modelling.Advances in experimental medicine and biology · 2021Article
- Parkinson's Disease and the Gut: Future Perspectives for Early Diagnosis.Frontiers in neuroscience · 2020Review
- Ameliorative effects of crocin on paraquat-induced oxidative stress in testis of adult mice: An experimental study.International journal of reproductive biomedicine · 2019Article
- Stem cell therapy for Parkinson's disease using non-human primate models.Zoological research · 2019Review
- Assessment of fipronil toxicity on wistar rats: A hepatotoxic perspective.Toxicology reports · 2018Article
- Clinical effects of chemical exposures on mitochondrial function.Toxicology · 2017Review
- Editor's Highlight: Base Excision Repair Variants and Pesticide Exposure Increase Parkinson's Disease Risk.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Paraquat and Parkinson's disease: a systematic review protocol according to the OHAT approach for hazard identification.Systematic reviews · 2017Article
- Multifactorial theory applied to the neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease.Laboratory investigation; a journal of technical methods and pathology · 2016Review
- Parkinson's Disease: The Mitochondria-Iron Link.Parkinson's disease · 2016Review
- Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases.Frontiers in cellular neuroscience · 2015Review
- Traumatic brain injury, paraquat exposure, and their relationship to Parkinson disease.Neurology · 2012Article
- Genetic modification of the association of paraquat and Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pesticide paraquat (PQ) was found to be a suitable xenobiotic to model Parkinson's disease. The reactive oxygen species (ROS) production was suggested to be the main cause of PQ toxicity but very few evidences were found for its generation in the brain in vivo after ip administration. We compared the effects of PQ-induced ROS generation between the brain structures and the peripheral tissues using two different hydroxyl radical generation markers. Repeated but not single ip PQ administration increased the levels of ROS in the striatal homogenates but, when measured in the extracellular microdialysis filtrate, no change was observed. The increased dopamine release was detected in the striatum after the fourth PQ administration and its basal levels were decreased. A single treatment with the pesticide did not influence ROS production in the lungs or kidneys but repeated intoxication decreased its levels. These results suggest that repeated, systemic administration of a low dose of PQ triggers intracellular ROS formation in the brain and can cause slowly progressing degenerative processes, without the toxic effects in the peripheral tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.