ArticleNeurochemical research2010
Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, interacts with pleiotrophin, a heparin-binding growth factor.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 21 citations in OpenAlex.
- MDIC3: Matrix decomposition to infer cell-cell communication.Patterns (New York, N.Y.) · 2024Article
- The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Neural Tissue Homeostasis and Repair Is Regulated via CS and DS Proteoglycan Motifs.Frontiers in cell and developmental biology · 2021Review
- Adiposity-related insulin resistance and thickness of the cerebral cortex in middle-aged adults.Journal of neuroendocrinology · 2020Article
- Proteoglycans and neuronal migration in the cerebral cortex during development and disease.Frontiers in neuroscience · 2015Review
- Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus.Frontiers in cellular neuroscience · 2014Review
- Chondroitin sulfate "wobble motifs" modulate maintenance and differentiation of neural stem cells and their progeny.The Journal of biological chemistry · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroglycan C (NGC) is a transmembrane-type chondroitin sulfate proteoglycan that promotes neurite outgrowth. To identify the ligand of NGC, we applied a detergent-solubilized membrane fraction of fetal rat brains to an NGC-immobilized affinity column. Several proteins were eluted from the column including an 18 kDa-band protein recognized by an anti-pleiotrophin antibody. The binding of pleiotrophin (PTN) to NGC was confirmed by a quartz crystal microbalance method and had a Kd of 8.7 nM. PTN bound to the acidic amino acid cluster of the NGC extracellular domain. In addition, PTN bound to both chondroitin sulfate-bearing NGC and chondroitinase-treated NGC prepared from the neonatal rat brain. These results suggest that NGC interacts with PTN.
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Registered trials
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