ArticleCardiology research and practice2010
Statins Decrease Oxidative Stress and ICD Therapies.
Article in Cardiology research and practice, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045043 (Genetic Risk Assessment of Defibrillator Events), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Risk Assessment of Defibrillator Events: A Prospective Multicenter Observational Study
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- The Influence of Atorvastatin Treatment on Homocysteine Metabolism and Oxidative Stress in an Experimental Model of Diabetic Rats.Life (Basel, Switzerland) · 2024Article
- Redox imbalance in patients with heart failure and ICD/CRT-D intervention. Can it be an underappreciated and overlooked arrhythmogenic factor? A first preliminary clinical study.Frontiers in physiology · 2023Article
- The Prognostic Value of Derivatives-Reactive Oxygen Metabolites (d-ROMs) for Cardiovascular Disease Events and Mortality: A Review.Antioxidants (Basel, Switzerland) · 2022Review
- Antioxidants in Arrhythmia Treatment-Still a Controversy? A Review of Selected Clinical and Laboratory Research.Antioxidants (Basel, Switzerland) · 2022Review
- Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study.Scientific reports · 2021Article
- MicroRNAs Bioinformatics Analyses Identifying HDAC Pathway as a Putative Target for Existing Anti-COVID-19 Therapeutics.Frontiers in pharmacology · 2020Article
- Effect of the interaction between atorvastatin and selective serotonin reuptake inhibitors on the blood redox equilibrium.Experimental and therapeutic medicine · 2016Article
- Status of systemic oxidative stress during therapeutic hypothermia in patients with post-cardiac arrest syndrome.Oxidative medicine and cellular longevity · 2013Article
- EPR studies on hydroxyl radical-scavenging activities of pravastatin and fluvastatin.Molecular and cellular biochemistry · 2012Article
- Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy.Heart rhythm · 2012Article
- Simvastatin protects osteoblast against H2O2-induced oxidative damage via inhibiting the upregulation of Nox4.Molecular and cellular biochemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies demonstrate that statins decrease ventricular arrhythmias in internal cardioverter defibrillator (ICD) patients. The mechanism is unknown, but evidence links increased inflammatory and oxidative states with increased arrhythmias. We hypothesized that statin use decreases oxidation. Methods. 304 subjects with ICDs were surveyed for ventricular arrhythmia. Blood was analyzed for derivatives of reactive oxygen species (DROMs) and interleukin-6 (IL-6). Results. Subjects included 252 (83%) men, 58% on statins, 20% had ventricular arrhythmias. Average age was 63 years and ejection fraction (EF) 20%. ICD implant duration was 29 +/- 27 months. Use of statins correlated with lower ICD events (r = 0.12, P = .02). Subjects on statins had lower hsCRP (5.2 versus 6.3; P = .05) and DROM levels (373 versus 397; P = .03). Other factors, including IL-6 and EF did not differ between statin and nonstatin use, nor did beta-blocker or antiarrhythmic use. Multivariate cross-correlation analysis demonstrated that DROMs, statins, IL-6 and EF were strongly associated with ICD events. Multivariate regression shows DROMs to be the dominant predictor. Conclusion. ICD event rate correlates with DROMs, a measure of lipid peroxides. Use of statins is associated with reduced DROMs and fewer ICD events, suggesting that statins exert their effect through reducing oxidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.