ArticleInternational journal of clinical and experimental medicine2010
Effects of simulated weightlessness on liver Hsp70 and Hsp70mRNA expression in rats.
Article in International journal of clinical and experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Microgravity and Human Body: Unraveling the Potential Role of Heat-Shock Proteins in Spaceflight and Future Space Missions.Biology · 2024Review
- Influence of ferulic acid consumption in ameliorating the cadmium-induced liver and renal oxidative damage in rats.Environmental science and pollution research international · 2019Article
- Supplying a pharmacy for NASA exploration spaceflight: challenges and current understanding.NPJ microgravity · 2019Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Space flight is known to induce a number of hepatic physiological alterations. In this study, we investigated Hsp70 expressing features of rat liver under simulated weightlessness. Tail-suspension was used to simulate the weightlessness animal model. Forty-eight male Wistar rats were randomly assigned to 6 experimental groups and Hsp70 protein and mRNA expressions in the liver were detected by Western blot and RT-PCR respectively. The tail-suspension significantly increased Hsp70mRNA expression levels in rat liver (P<0.05). The semi-quantitative PCR showed that Hsp70mRNA was upregulated as early as 6 hours of suspension. Western blot analysis indicated that Hsp70 protein was significantly upregulated in the early stage of suspension as compared with controls (P<0.05). The results suggest that simulated weightlessness acts as a kind of stress to elevate liver Hsp70 expression both at protein and mRNA levels. This may be meaningful in astronaut's trainings by preadaptation to non-damaging stress exposures or other environmental factors to foster the astronaut's ability of weightless tolerance.
Indexed as
Identifiers
20369040PMC2848306W64801733What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.