ArticlePLoS pathogens2010
A genomic survey of positive selection in Burkholderia pseudomallei provides insights into the evolution of accidental virulence.
Article in PLoS pathogens, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
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Who cites it
73 citing papers in PubMed, 150 citations in OpenAlex.
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- Human infections caused by pathogenic Burkholderia: current clinical challenges and future perspectives.Infection · 2026Review
- Ecological Diversity, Metabolic Versatility, and Biotechnological Applications ofAntibiotics (Basel, Switzerland) · 2025Review
- Metabolomic profiling ofmSystems · 2025Article
- Genome analysis of Actinobacillus pleuropneumoniae strain APPFJLYC01 reveals multidrug resistance and high virulence potential.PloS one · 2025Article
- Co-isolation of genetically distinct Burkholderia pseudomallei strains from a single patient in North Queensland.PloS one · 2025Article
- Whole-Genome Sequence and Characterization ofGenes · 2024Article
- Mitochondrial Genomes ofAnimals : an open access journal from MDPI · 2024Article
- Genomics Analysis Reveals the Potential Biocontrol Mechanism ofJournal of fungi (Basel, Switzerland) · 2024Article
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- Isolation, Identification, Antimicrobial Resistance, Genotyping, and Whole-Genome Sequencing Analysis ofPolish journal of microbiology · 2024Article
- A Novel Bacillus Velezensis for Efficient Degradation of Zearalenone.Foods (Basel, Switzerland) · 2024Article
- Comparative genomic analysis ofFrontiers in microbiology · 2024Article
- Genomic and proteomic analysis of Salmonella Enteritidis isolated from a patient with foodborne diarrhea.World journal of microbiology & biotechnology · 2023Article
- The Resistance and Virulence Characteristics ofInfection and drug resistance · 2023Article
- Mining of key genes for cold adaptation fromFrontiers in microbiology · 2023Article
- Phenotypic and genetic alterations ofFrontiers in microbiology · 2023Article
- A genome-wide scan of wastewater E. coli for genes under positive selection: focusing on mechanisms of antibiotic resistance.Scientific reports · 2022Article
- A type IVB pilin influences twitching motility andMicrobiology (Reading, England) · 2022Article
- A clinicalFrontiers in microbiology · 2022Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
23 authors at 8 institutions in 5 countries.
Funding
Abstract
Certain environmental microorganisms can cause severe human infections, even in the absence of an obvious requirement for transition through an animal host for replication ("accidental virulence"). To understand this process, we compared eleven isolate genomes of Burkholderia pseudomallei (Bp), a tropical soil microbe and causative agent of the human and animal disease melioidosis. We found evidence for the existence of several new genes in the Bp reference genome, identifying 282 novel genes supported by at least two independent lines of supporting evidence (mRNA transcripts, database homologs, and presence of ribosomal binding sites) and 81 novel genes supported by all three lines. Within the Bp core genome, 211 genes exhibited significant levels of positive selection (4.5%), distributed across many cellular pathways including carbohydrate and secondary metabolism. Functional experiments revealed that certain positively selected genes might enhance mammalian virulence by interacting with host cellular pathways or utilizing host nutrients. Evolutionary modifications improving Bp environmental fitness may thus have indirectly facilitated the ability of Bp to colonize and survive in mammalian hosts. These findings improve our understanding of the pathogenesis of melioidosis, and establish Bp as a model system for studying the genetics of accidental virulence.
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