ArticleMolecular psychiatry2011
TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies.
Article in Molecular psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 12 of them syntheses that pooled it.
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Who cites it
82 citing papers in PubMed, 12 syntheses or guidelines pooled it, 183 citations in OpenAlex.
- Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.Molecular psychiatry · 2026Pooled it
- Beyond fear circuits: multiscale neurobiological architecture of panic disorder.Molecular psychiatry · 2026Pooled it
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling.Nature genetics · 2026Pooled it
- Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.Molecular psychiatry · 2021Pooled it
- Pooled it
- Genome-wide association study of shared liability to anxiety disorders in Army STARRS.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Pooled it
- A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders.Translational psychiatry · 2019Pooled it
- Meta-analysis of genome-wide association studies of anxiety disorders.Molecular psychiatry · 2016Pooled it
- Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways.Molecular psychiatry · 2016Pooled it
- Meta-analysis of genome-wide association studies for panic disorder in the Japanese population.Translational psychiatry · 2012Pooled it
- Replication and meta-analysis of TMEM132D gene variants in panic disorder.Translational psychiatry · 2012Pooled it
- Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.Biological psychiatry · 2011Pooled it
- MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy.Molecular psychiatry · 2014Trial
- LiMA: Robust inference of molecular mediation from summary statistics.American journal of human genetics · 2026Article
- Epigenetic markers of disease risk and psychotherapy response in anxiety disorders - a longitudinal analysis of the DNA methylome.Molecular psychiatry · 2025Article
- Molecular Basis of Anxiety: A Comprehensive Review of 2014-2024 Clinical and Preclinical Studies.International journal of molecular sciences · 2025Review
- Cortex-SpecificThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dysregulated Gene Expression: A Candidate Mechanism for Anxiety Disorders.Journal of psychiatry and brain science · 2025Article
- Review on GPU accelerated methods for genome-wide SNP-SNP interactions.Molecular genetics and genomics : MGG · 2024Review
- Single prolonged stress induces behavior and transcriptomic changes in the medial prefrontal cortex to increase susceptibility to anxiety-like behavior in rats.Frontiers in psychiatry · 2024Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
40 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lifetime prevalence of panic disorder (PD) is up to 4% worldwide and there is substantial evidence that genetic factors contribute to the development of PD. Single-nucleotide polymorphisms (SNPs) in TMEM132D, identified in a whole-genome association study (GWAS), were found to be associated with PD in three independent samples, with a two-SNP haplotype associated in each of three samples in the same direction, and with a P-value of 1.2e-7 in the combined sample (909 cases and 915 controls). Independent SNPs in this gene were also associated with the severity of anxiety symptoms in patients affected by PD or panic attacks as well as in patients suffering from unipolar depression. Risk genotypes for PD were associated with higher TMEM132D mRNA expression levels in the frontal cortex. In parallel, using a mouse model of extremes in trait anxiety, we could further show that anxiety-related behavior was positively correlated with Tmem132d mRNA expression in the anterior cingulate cortex, central to the processing of anxiety/fear-related stimuli, and that in this animal model a Tmem132d SNP is associated with anxiety-related behavior in an F2 panel. TMEM132D may thus be an important new candidate gene for PD as well as more generally for anxiety-related behavior.
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Registered trials
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