ArticleAnnals of internal medicine2010
A model-based estimate of cumulative excess mortality in survivors of childhood cancer.
Article in Annals of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02114697 (Accelerated Atherosclerosis in High Risk Population Groups), which is not on this map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- A worldwide collaboration to harmonize guidelines for the long-term follow-up of childhood and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group.Pediatric blood & cancer · 2013Guideline
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- Implementing a mHealth intervention to increase colorectal cancer screening among high-risk cancer survivors treated with radiotherapy in the Childhood Cancer Survivor Study (CCSS).BMC health services research · 2022Article
- Cancer Treatment-Induced Accelerated Aging in Cancer Survivors: Biology and Assessment.Cancers · 2021Review
- High molecular weight adiponectin levels are inversely associated with adiposity in pediatric brain tumor survivors.Scientific reports · 2020Article
- Life Expectancy of Adult Survivors of Childhood Cancer Over 3 Decades.JAMA oncology · 2020Article
- Current and coming challenges in the management of the survivorship population.Seminars in oncology · 2020Review
- Association of Exercise With Mortality in Adult Survivors of Childhood Cancer.JAMA oncology · 2018Article
- Evidence From Ghana Indicates That Childhood Cancer Treatment in Sub-Saharan Africa Is Very Cost Effective: A Report From the Childhood Cancer 2030 Network.Journal of global oncology · 2018Article
- The Children's Oncology Group Radiation Oncology Discipline: 15 Years of Contributions to the Treatment of Childhood Cancer.International journal of radiation oncology, biology, physics · 2018Review
- Article
- Future cancer research priorities in the USA: a Lancet Oncology Commission.The Lancet. Oncology · 2017Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAlthough childhood cancer survival rates have dramatically increased, survivors face elevated risk for life-threatening late effects, including secondary cancer.
objectiveTo estimate the cumulative effect of disease- and treatment-related mortality risks on survivor life expectancy.
designState-transition model to simulate the lifetime clinical course of childhood cancer survivors.
settingChildhood Cancer Survivor Study. PATIENTS: Five-year survivors of childhood cancer. MEASUREMENTS: Probabilities of risk for death from the original cancer diagnosis, excess mortality from subsequent cancer and cardiac, pulmonary, external, and other complications, and background mortality (age-specific mortality rates for the general population) were estimated over the lifetime of survivors of childhood cancer.
resultsFor a cohort of 5-year survivors aged 15 years who received a diagnosis of cancer at age 10 years, the average lifetime probability was 0.10 for late-recurrence mortality; 0.15 for treatment-related subsequent cancer and death from cardiac, pulmonary, and external causes; and 0.05 for death from other excess risks. Life expectancy for the cohort of persons aged 15 years was 50.6 years, a loss of 10.4 years (17.1%) compared with the general population. Reduction in life expectancy varied by diagnosis, ranging from 4.0 years (6.0%) for kidney tumor survivors to more than 17.8 years (> or =28.0%) for brain and bone tumor survivors, and was sensitive to late-recurrence mortality risk and duration of excess mortality risk. LIMITATION: Estimates are based on data for survivors who received treatment 20 to 40 years ago; patients who received treatment more recently may have more favorable outcomes.
conclusionChildhood cancer survivors face considerable mortality during adulthood, with excess risks reducing life expectancy by as much as 28%. Monitoring the health of current survivors and carefully evaluating therapies with known late toxicities in patients with newly diagnosed cancer are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.