ArticleArchives of pediatrics & adolescent medicine2010
Headache and biomarkers predictive of vascular disease in a representative sample of US children.
Article in Archives of pediatrics & adolescent medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Effect of fasting-induced headache on calcitonin gene related peptide (CGRP) and other clinical biomarkers on the first day of Ramadan: Sub-analysis from a randomized open label clinical trial.The journal of headache and pain · 2024Trial
- Reduced Serum Uric Acid and Albumin Levels in Patients with Migraine: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Relationship between cognitive disengagement syndrome and headache in children: insights from biochemical markers.Frontiers in psychiatry · 2025Article
- Could headache in children be a biomarker for dyslipidemia?Acta neurologica Belgica · 2024Article
- Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2024Article
- Serological Biomarkers of Chronic Migraine.Current pain and headache reports · 2023Review
- Migraine: Advances in the Pathogenesis and Treatment.Neurology international · 2023Review
- The Effects of Vitamin B-Complex Supplementation on Serum Homocysteine Levels and Migraine Severity in Children A Randomized Controlled Trial.Iranian journal of child neurology · 2023Article
- Selected Factors of Vascular Changes: The Potential Pathological Processes Underlying Primary Headaches in Children.Children (Basel, Switzerland) · 2022Article
- A study on the correlation between pain frequency and severity and vitamin B12 levels in episodic and chronic migraine.Arquivos de neuro-psiquiatria · 2022Article
- No change in interictal C-reactive protein levels in individuals with episodic and chronic migraine: A case-control study and literature review.Frontiers in neurology · 2022Article
- Evaluation of serum uric levels in migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Headache in Children: Selected Factors of Vascular Changes Involved in Underlying Processes of Idiopathic Headaches.Children (Basel, Switzerland) · 2020Review
- The impact of C-reactive protein levels on headache frequency in the HUNT study 2006-2008.BMC neurology · 2019Article
- Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches - a preliminary report.Archives of medical science : AMS · 2019Article
- Migraine and vascular disease biomarkers: A population-based case-control study.Cephalalgia : an international journal of headache · 2018Article
- Vitamin D in Children's Health.Children (Basel, Switzerland) · 2014Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association of childhood headache disorders with markers of risk for cardiovascular and cerebrovascular disease.
designInformation was collected on severe or recurrent headache or migraine in childhood or adolescence and on biomarkers predictive of vascular disease.
settingThe National Health and Nutrition Survey, a nationally representative health survey.
participantsChildren or adolescents aged 4 to 19 years (n = 11 770) who took part in the National Health and Nutrition Survey in 1999 through 2004. MAIN EXPOSURE: Headache.
main outcome measuresBody mass index; levels of C-reactive protein, homocysteine, serum and red blood cell folate, vitamin B(12), methylmalonic acid, total cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, triglycerides, and uric acid; and platelet count.
resultsMean values for body mass index, C-reactive protein, and homocysteine were higher in children with than without headaches, and more children with headaches were in the highest quintile of risk for these factors. Serum and red blood cell folate levels were lower in children with headache. More children with headache were in the highest quintile of risk for 3 or more of these factors.
conclusionsSeveral important risk factors for long-term vascular morbidity cluster in children and adolescents with severe or recurrent headache or migraine. Further study and screening of children with headaches may permit improved preventive management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.