ArticleProceedings of the National Academy of Sciences of the United States of America2010
Role of pre- and postsynaptic activity in thalamocortical axon branching.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed.
- Cell-type-selective synaptogenesis during the development of layer 6 corticothalamic neuron connectivity in the mammalian neocortex.Cell reports · 2026Article
- Neuronal growth patterns and synapse formation are mediated by distinct activity-dependent mechanisms.Scientific reports · 2025Article
- Ex vivo cortical circuits learn to predict and spontaneously replay temporal patterns.Nature communications · 2025Article
- Neuromodulatory control of inhibitory network arborization in the developing postnatal neocortex.Science advances · 2022Article
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders.Frontiers in neuroscience · 2022Review
- Differential Excitability of PV and SST Neurons Results in Distinct Functional Roles in Inhibition Stabilization of Up States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination.Neuron · 2021Review
- Neuronal Activity Patterns Regulate Brain-Derived Neurotrophic Factor Expression in Cortical CellsFrontiers in neuroscience · 2021Article
- Elongated EABR wave latencies observed in patients with auditory neuropathy caused byLaryngoscope investigative otolaryngology · 2018Article
- Activity-Dependent Myelination of Parvalbumin Interneurons Mediated by Axonal Morphological Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures.Journal of visualized experiments : JoVE · 2018Article
- Diversity and Connectivity of Layer 5 Somatostatin-Expressing Interneurons in the Mouse Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Nucleocytoplasmic Shuttling of Histone Deacetylase 9 Controls Activity-Dependent Thalamocortical Axon Branching.Scientific reports · 2017Article
- Quantitative Analysis of Axonal Branch Dynamics in the Developing Nervous System.PLoS computational biology · 2016Article
- Neuronal activity is not required for the initial formation and maturation of visual selectivity.Nature neuroscience · 2015Article
- Excitability governs neural development in a hippocampal region-specific manner.Development (Cambridge, England) · 2015Article
- Flow- and voltage-dependent blocking effect of ethosuximide on the inward rectifier K⁺ (Kir2.1) channel.Pflugers Archiv : European journal of physiology · 2015Article
- A short splicing isoform of afadin suppresses the cortical axon branching in a dominant-negative manner.Molecular biology of the cell · 2015Article
- Netrin-4 regulates thalamocortical axon branching in an activity-dependent fashion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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6 authors.
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Abstract
Axonal branching is thought to be regulated not only by genetically defined programs but also by neural activity in the developing nervous system. Here we investigated the role of pre- and postsynaptic activity in axon branching in the thalamocortical (TC) projection using organotypic coculture preparations of the thalamus and cortex. Individual TC axons were labeled with enhanced yellow fluorescent protein by transfection into thalamic neurons. To manipulate firing activity, a vector encoding an inward rectifying potassium channel (Kir2.1) was introduced into either thalamic or cortical cells. Firing activity was monitored with multielectrode dishes during culturing. We found that axon branching was markedly suppressed in Kir2.1-overexpressing thalamic cells, in which neural activity was silenced. Similar suppression of TC axon branching was also found when cortical cell activity was reduced by expressing Kir2.1. These results indicate that both pre- and postsynaptic activity is required for TC axon branching during development.
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