Evidence map›Paper›PMID 20368369›Full record

ReviewMolecular interventions2010

Networking with AKAPs: context-dependent regulation of anchored enzymes.

Emily J Welch, Brian W Jones, John D Scott

Abstract readReview
In one paragraph

Review in Molecular interventions, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Defective I1 dynein inmicroPublication biology · 2025
    Article
  6. InDel and CNV within theAnimals : an open access journal from MDPI · 2023
    Article
  7. AKAP13 Enhances CREB1 Activation by FSH in Granulosa Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Article
  8. Article
  9. Biochemical Analysis of AKAP-Anchored PKA Signaling Complexes.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  10. GPharmacological reviews · 2021
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Synemin Redefined: Multiple Binding Partners Results in Multifunctionality.Frontiers in cell and developmental biology · 2020
    Review
  19. Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emily J WelchHoward Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Brian W Jones
John D Scott

Funding

Project# 4: INTERACTIONS OF ANCHORING PROTEINS WITH THEIR TARGETSP01DK054441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAYLOR, SUSAN S. · 1999 to 2017
$27.3M
Anchored Kinase Signaling Mechanisms in Cardiac HypertrophyR01HL088366 · NHLBI · UNIVERSITY OF WASHINGTON · PI SCOTT, JOHN D · 2008 to 2012
$2.0M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL088366NIDDK NIH HHS DK54441NIDDK NIH HHS P01 DK054441NIDDK NIH HHS P01DK54441
6 · The paper itself

Abstract

A-Kinase Anchoring Proteins (AKAPs) orchestrate and synchronize cellular events by tethering the cAMP-dependent protein kinase (PKA) and other signaling enzymes to organelles and membranes. The control of kinases and phosphatases that are held in proximity to activators, effectors, and substrates favors the rapid dissemination of information from one cellular location to the next. This article charts the inception of the PKA-anchoring hypothesis, the characterization of AKAPs and their nomenclature, and the physiological roles of context-specific AKAP signaling complexes.

Indexed as

Gene Expression Regulation, EnzymologicA Kinase Anchor ProteinsCyclic AMP-Dependent Protein KinasesEnzymes, ImmobilizedHumansModels, BiologicalModels, MolecularA Kinase Anchor ProteinsCyclic AMP-Dependent Protein KinasesEnzymes, Immobilized

Identifiers

PMID20368369
PMCPMC2895371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.