ArticlePediatrics2010
Blood lead levels and delayed onset of puberty in a longitudinal study of Russian boys.
Article in Pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.Pediatrics · 2024Article
- Challenges in health risk assessment of multiple chemical exposures in epidemiological studies.Environmental health and preventive medicine · 2024Article
- Pubertal progression in relation to peripubertal exposure to organochlorine chemicals in a cohort of Russian boys.International journal of hygiene and environmental health · 2023Article
- Article
- Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys.Environmental research · 2022Article
- Association of peripubertal blood lead levels with reproductive hormones and semen parameters in a longitudinal cohort of Russian men.Human reproduction (Oxford, England) · 2022Article
- Sex differences in the association of measures of sexual maturation to common toxicants: Lead, dichloro-diphenyl-trichloroethane (DDT), dichloro-diphenyl-dichloroethylene (DDE), and polychlorinated biphenyls (PCBs).Annals of human biology · 2021Review
- Lead exposure and indices of height and weight in Uruguayan urban school children, considering co-exposure to cadmium and arsenic, sex, iron status and dairy intake.Environmental research · 2021Article
- In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among boys in Mexico City.Environmental health : a global access science source · 2020Article
- Peripubertal serum concentrations of organochlorine pesticides and semen parameters in Russian young men.Environment international · 2020Article
- Urinary cadmium and timing of menarche and pubertal development in girls.Environmental research · 2020Article
- Risk for animal and human health related to the presence of dioxins and dioxin-like PCBs in feed and food.EFSA journal. European Food Safety Authority · 2018Article
- Peripubertal blood lead levels and growth among Russian boys.Environment international · 2017Article
- The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children's Study.Reviews on environmental health · 2017Review
- A Longitudinal Study of Peripubertal Serum Organochlorine Concentrations and Semen Parameters in Young Men: The Russian Children's Study.Environmental health perspectives · 2017Article
- Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys.Environmental health perspectives · 2015Article
- Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys.Environment international · 2014Article
- Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene (p,p'-DDE) with testosterone levels in adolescent males.Environmental health perspectives · 2014Article
- Blood lead levels and serum insulin-like growth factor 1 concentrations in peripubertal boys.Environmental health perspectives · 2013Article
- Genetic modification of the association between peripubertal dioxin exposure and pubertal onset in a cohort of Russian boys.Environmental health perspectives · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveWe evaluated the association of blood lead levels (BLLs) with pubertal onset in a longitudinal cohort of Russian boys.
methodsA total of 489 Russian boys were enrolled in 2003-2005, at 8 to 9 years of age, and were monitored annually through May 2008. Cox proportional-hazards models were used to evaluate the association of BLLs at enrollment with time to pubertal onset during follow-up monitoring.
resultsA total of 481 boys had BLLs, with a median of 3 microg/dL and 28% with values of > or =5 microg/dL. The proportion of pubertal boys increased with age, from 12% at age 8 to 83% at age 12 for testicular volume of >3 mL, from 22% to 90% for genitalia stage 2 or higher, and from 4% to 40% for pubic hair stage 2 or higher. After adjustment for potential confounders including BMI and height, boys with high BLLs (> or =5 microg/dL) had 24% to 31% reduced risk of pubertal onset, on the basis of testicular volume of >3 mL (hazard ratio [HR]: 0.73 [95% confidence interval [CI]: 0.55-0.97]; P = .03), genitalia staging (HR: 0.76 [95% CI: 0.59-0.98]; P = .04), and pubic hair staging (HR: 0.69 [95% CI: 0.44-1.07]; P = .10), compared with those with lower BLLs. Pubertal onset occurred 6 to 8 months later, on average, for boys with high BLLs, compared with those with BLLs of <5 microg/dL.
conclusionHigher BLLs were associated with later pubertal onset in this prospective study of peripubertal Russian boys.
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