Evidence map›Paper›PMID 20368285›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2010

Analysis of gamma delta T cell functions in the mouse.

Willi K Born, Zhinan Yin, Youn-Soo Hahn, Deming Sun, Rebecca L O'Brien

Abstract readComparative StudyReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. γδ T Lymphocytes in Asthma: a Complicated Picture.Archivum immunologiae et therapiae experimentalis · 2021
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. γδ T Cells Contribute to Injury in the Developing Brain.The American journal of pathology · 2018
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Willi K BornIntegrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA. bornw@njhealth.org
Zhinan Yin
Youn-Soo Hahn
Deming Sun
Rebecca L O'Brien

Funding

UVA Digestive Health Research CenterP30DK067629 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI PIZARRO, THERESA TORRES · 2004 to 2008
$5.6M
Role of IL-17+ Autoreactive T Cells in Experimental Autoimmune Uveitis (EAU)R01EY018827 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 2009 to 2023
$4.8M
The Basis of Functional Variation in Gamma/Delta T cellsR01AI044920 · NIAID · NATIONAL JEWISH HEALTH · PI O'BRIEN, REBECCA L. · 1999 to 2009
$3.0M
AIRWAY FUNCTION--ROLE OF GAMMA DELTA T CELLSR01HL065410 · NHLBI · NATIONAL JEWISH HEALTH · PI BORN, WILLI K · 2000 to 2007
$2.7M
Progression of Uveitis and CD8 uveitogenic T cellsR01EY017373 · NEI · UNIVERSITY OF LOUISVILLE · PI SUN, DEMING · 2007 to 2011
$1.5M
RESPONSE OF GAMMA/DELTA T CELLS TO CARDIOLIPIN AND DNAR01AI040611 · NIAID · NATIONAL JEWISH HEALTH · PI BORN, WILLI K · 1997 to 2004
$1.3M
Identifying Ligands with Soluble Gamma/Delta TCRsR21AI063400 · NIAID · NATIONAL JEWISH HEALTH · PI O'BRIEN, REBECCA L. · 2005 to 2006
$422k
NEI NIH HHS R01 EY017373NEI NIH HHS R01 EY018827NHLBI NIH HHS HL65410NHLBI NIH HHS R01 HL065410NIAID NIH HHS AI063400NIAID NIH HHS AI40611NIAID NIH HHS AI44920NIAID NIH HHS R01 AI040611NIAID NIH HHS R01 AI044920NIAID NIH HHS R21 AI063400NIDDK NIH HHS P30 DK067629
6 · The paper itself

Abstract

Mouse models of disease and injury have been invaluable in investigations of the functional role of gammadelta T cells. They show that gammadelta T cells engage in immune responses both early and late, that they can function both polyclonally and as peripherally selected clones, and that they can be effector cells and immune regulators. They also suggest that functional development of gammadelta T cells occurs stepwise in thymus and periphery, and that it is governed by gammadelta TCR-signaling and other signals. Finally, they indicate that gammadelta T cell functions often segregate with TCR-defined subsets, in contrast to conventional T cells. From the functional studies in mice and other animal models, gammadelta T cells emerge as a distinct lymphocyte population with a unique and broad functional repertoire, and with important roles in Ab responses, inflammation and tissue repair. They also are revealed as a potentially useful target for immune intervention.

Indexed as

Models, AnimalAnimalsCell DifferentiationDisease Models, AnimalHumansInflammation MediatorsMiceReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSignal TransductionThymus GlandT-Lymphocyte SubsetsInflammation MediatorsReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID20368285
PMCPMC4476288

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.