ArticleBehavioral neuroscience2010
Suppression of third ventricular NPY-elicited feeding following medullary reticular formation infusions of muscimol.
Article in Behavioral neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- A genetically defined pontine nucleus essential for ingestion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Central Mechanisms of Thermoregulation and Fever in Mammals.Advances in experimental medicine and biology · 2024Review
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- A hypothalamomedullary network for physiological responses to environmental stresses.Nature reviews. Neuroscience · 2022Review
- The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections.Nutrients · 2021Article
- Article
- Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability.Pflugers Archiv : European journal of physiology · 2018Review
- Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions.Neuroscience · 2018Review
- Medullary Reticular Neurons Mediate Neuropeptide Y-Induced Metabolic Inhibition and Mastication.Cell metabolism · 2017Article
- Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons.Frontiers in neuroanatomy · 2015Article
- How the brainstem controls orofacial behaviors comprised of rhythmic actions.Trends in neurosciences · 2014Review
- More than a rhythm of life: breathing as a binder of orofacial sensation.Nature neuroscience · 2014Review
- The Brainstem Oscillator for Whisking and the Case for Breathing as the Master Clock for Orofacial Motor Actions.Cold Spring Harbor symposia on quantitative biology · 2014Article
- Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Satiation and stress-induced hypophagia: examining the role of hindbrain neurons expressing prolactin-releasing Peptide or glucagon-like Peptide 1.Frontiers in neuroscience · 2012Article
- μ-Opioid modulation in the rostral solitary nucleus and reticular formation alters taste reactivity: evidence for a suppressive effect on consummatory behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Terminal field specificity of forebrain efferent axons to the pontine parabrachial nucleus and medullary reticular formation.Brain research · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The appetitive component of feeding is controlled by forebrain substrates, but the consummatory behaviors of licking, mastication, and swallowing are organized in the brainstem. The target of forebrain appetitive signals is unclear but likely includes regions of the medullary reticular formation (RF). This study was undertaken to determine the necessity of different RF regions for mastication induced by a descending appetitive signal. We measured solid food intake in response to third ventricular (3V) infusions of the orexigenic peptide neuropeptide Y 3-36 in awake, freely moving rats and determined whether focal RF infusions of the GABAA agonist muscimol suppressed eating. RF infusions were centered in either the lateral tegmental field, comprising the intermediate (IRt) and parvocellular (PCRt) RF, or in the nucleus gigantocellularis (Gi). Infusions of NPY 3-36 (5 microg/5 microl) into 3V significantly increased feeding of solid food over a 90-min period compared with the noninfused condition (4.3 g +/- 0.56 vs. 0.57 g +/- 0.57, p < .001). NPY 3-36-induced food intake was suppressed (1.7 g +/- 0.48) by simultaneous infusions of muscimol (0.6 mM/100 nl) into the IRt/PCRt (p < .01). Coincident with the decrease in feeding was a decrease in the amplitude of anterior digastric muscle contractions in response to intraoral sucrose infusions. In contrast, infusions of muscimol into Gi had no discernible effect on food intake or EMG amplitude. These data suggest that the IRt/PCRt is essential for forebrain-initiated mastication, but that the Gi is not a necessary link in this pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.