Evidence map›Paper›PMID 20364413›Full record

ReviewWiener medizinische Wochenschrift (1946)2010

The vagal immune reflex: a blessing from above.

David J van Westerloo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Wiener medizinische Wochenschrift (1946), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Berberine relieves insulin resistance via the cholinergic anti-inflammatory pathway in HepG2 cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016
    Article
  6. Sensorineural Tinnitus: Its Pathology and Probable Therapies.International journal of otolaryngology · 2016
    Review
  7. Influence of vagal injury on acute traumatic reaction after blast injury.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2013
    Article
  8. The effect of light on critical illness.Critical care (London, England) · 2011
    Review
  9. Review
  10. Editorial: sepsis.Wiener medizinische Wochenschrift (1946) · 2010
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

David J van WesterlooAcademic Medical Center, Department of Intensive Care, University of Amsterdam, Amsterdam, The Netherlands. d.j.vanwesterloo@amc.uva.nl
Academic Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The innate immune response is activated upon recognition of infection or injury. A tight regulation of this inflammatory response is vital to ensure that it does not spin out of control and becomes harmful to the host. Recently, a neural circuit has been identified that controls the inflammatory response in a reflex-like manner. This circuit involves the vagus nerve which is able to sense inflammation and to respond to it by releasing acetylcholine which, through an interaction with immune cells, dampens the inflammatory response. The current knowledge regarding this "vagal immune reflex" is discussed with an emphasis on its role in sepsis.

Indexed as

AcetylcholineAnimalsAutonomic Nervous SystemHumansImmunity, InnateInflammation MediatorsReflexSepsisSystemic Inflammatory Response SyndromeVagus NerveVagus Nerve StimulationAcetylcholineInflammation Mediators

Identifiers

PMID20364413
OpenAlexW2601405855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.