ReviewWiener medizinische Wochenschrift (1946)2010
Update on the role of Toll-like receptors during bacterial infections and sepsis.
Review in Wiener medizinische Wochenschrift (1946), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- TLR4 knockdown by miRNA-140-5p improves tendinopathy: anArchives of medical science : AMS · 2024Article
- A phospho-tyrosine-based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity.Science advances · 2022Article
- Enriched environment housing improved the laying hen's resistance to transport stress via modulating the heat shock protective response and inflammation.Poultry science · 2021Article
- Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies.Frontiers in cell and developmental biology · 2021Review
- Circulating lncRNA ITSN1-2 is upregulated, and its high expression correlates with increased disease severity, elevated inflammation, and poor survival in sepsis patients.Journal of clinical laboratory analysis · 2019Article
- Triaryl Pyrazole Toll-Like Receptor Signaling Inhibitors: Structure-Activity Relationships Governing Pan- and Selective Signaling Inhibitors.ChemMedChem · 2018Article
- Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.Science signaling · 2018Article
- Effects of Pseudomonas aeruginosa and Streptococcus mitis mixed infection on TLR4-mediated immune response in acute pneumonia mouse model.BMC microbiology · 2017Article
- Corilagin ameliorates the extreme inflammatory status in sepsis through TLR4 signaling pathways.BMC complementary and alternative medicine · 2017Article
- Expression of Toll-like receptors (TLRs) in the lungs of an experimental sepsis mouse model.PloS one · 2017Article
- Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications.Cell death and differentiation · 2016Review
- Toll-like receptor 2 in serum: a potential diagnostic marker of prosthetic joint infection?Journal of clinical microbiology · 2014Article
- Toll-Like Receptor Activation in Immunity vs. Tolerance in Autoimmune Diabetes.Frontiers in immunology · 2014Review
- Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptides.The Journal of biological chemistry · 2012Article
- Editorial: sepsis.Wiener medizinische Wochenschrift (1946) · 2010Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) are recognition molecules that importantly contribute to the innate immune response to bacterial and viral infections. Once TLRs sense the presence of invading pathogens a signal transduction cascade is initiated that eventually leads to the production of pro-inflammatory mediators and attraction of neutrophils to the site of infection. While the ultimate goal of this defense pathway is the successful elimination of invading microbes, prolonged or exaggerated stimulation of TLR-associated events can lead to systemic inflammation and clinical symptoms of sepsis. This brief review summarizes the impact of selected TLRs in the host response to clinically important bacteria and provides insights into TLR-associated therapeutic approaches during sepsis and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.