ArticleMycopathologia2010
Paracoccidioides brasiliensis uses endogenous and exogenous arachidonic acid for PGE x production.
Article in Mycopathologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Can nonsteroidal anti-inflammatory drugs (NSAIDs) be repurposed for fungal infection?Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Eicosanoid production byVirulence · 2019Review
- 43 kDa Glycoprotein (gp43) fromJournal of immunology research · 2019Article
- Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells againstJournal of immunology research · 2019Article
- Severe Paracoccidioidomycosis in a 14-Year-Old Boy.Mycopathologia · 2016Article
- Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity.Journal of microbiology (Seoul, Korea) · 2016Review
- Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis.Mediators of inflammation · 2015Article
- Oxidized fatty acids as inter-kingdom signaling molecules.Molecules (Basel, Switzerland) · 2014Review
- Role of omega-3 polyunsaturated fatty acids in the production of prostaglandin E2 and nitric oxide during experimental murine paracoccidioidomycosis.BioMed research international · 2013Article
- Arachidonic acid metabolites in pathogenic yeasts.Lipids in health and disease · 2012Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis, the most prevalent deep mycosis in Latin America. Production of eicosanoids during fungal infections plays a critical role on fungal biology as well as on host immune response modulation. The purpose of our study was to assess whether P. brasiliensis strains with different degree of virulence (Pb18, Pb265, Bt79, Pb192) produce prostaglandin E(x) (PGE(x)). Moreover, we asked if P. brasiliensis could use exogenous sources of arachidonic acid (AA), as well as metabolic pathways dependent on cyclooxygenase (COX) enzyme, as reported for mammalian cells. A possible association between this prostanoid and fungus viability was also assessed. Our results showed that all strains, independently of their virulence, produce high PGE(x) levels on 4 h culture that were reduced after 8 h. However, in both culture times, higher prostanoid levels were detected after supplementation of medium with exogenous AA. Treatment with indomethacin, a COX inhibitor, induced a reduction on PGEx, as well as in fungus viability. The data provide evidence that P. brasiliensis produces prostaglandin-like molecules by metabolizing either endogenous or exogenous AA. Moreover, the results suggest the involvement of these mediators on fungal viability.
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