ArticlePlant cell reports2010
Stress and developmental responses of terpenoid biosynthetic genes in Cistus creticus subsp. creticus.
Article in Plant cell reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 67 citations in OpenAlex.
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- Determining the optimal antioxidant strategy: a comparative analysis of extraction methods inTurkish journal of biology = Turk biyoloji dergisi · 2025Article
- Effects of light spectra on morphological characteristics, primary and specialized metabolites ofHeliyon · 2024Article
- Identification of two terpenoids that accumulate in Chinese water chestnut in response to fresh-cut processing.Food science & nutrition · 2023Article
- Overexpression ofForestry research · 2023Article
- Proteomic Analysis Revealed Different Molecular Mechanisms of Response to PEG Stress in Drought-Sensitive and Drought-Resistant Sorghums.International journal of molecular sciences · 2022Article
- Transcriptome sequencing and differential expression analysis of natural and BTH-treated wound healing in potato tubers (Solanum tuberosum L.).BMC genomics · 2022Article
- Functional characterisation of the transcriptome from leaf tissue of the fluoroacetate-producing plant, Dichapetalum cymosum, in response to mechanical wounding.Scientific reports · 2020Article
- Comparative transcriptome analysis reveals the genes and pathways involved in terminal drought tolerance in pearl millet.Plant molecular biology · 2020Article
- Effects of Pre-Processing Hot-Water Treatment on Aroma Relevant VOCs of Fresh-Cut Apple Slices Stored in Sugar Syrup.Foods (Basel, Switzerland) · 2020Article
- Improving Phenolic Total Content and Monoterpene inInternational journal of molecular sciences · 2019Article
- Review
- Functional Identification ofFrontiers in plant science · 2019Article
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- HMG-CoA reductase from Camphor Tulsi (Ocimum kilimandscharicum) regulated MVA dependent biosynthesis of diverse terpenoids in homologous and heterologous plant systems.Scientific reports · 2018Article
- Ozone-triggered surface uptake and stress volatile emissions in Nicotiana tabacum 'Wisconsin'.Journal of experimental botany · 2018Article
- Differential regulation of volatile emission fromEnvironmental and experimental botany · 2018Article
- Environmental stress is the major cause of transcriptomic and proteomic changes in GM and non-GM plants.Scientific reports · 2017Article
- De novo transcriptome sequencing and gene expression profiling of spinach (Spinacia oleracea L.) leaves under heat stress.Scientific reports · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Plants, and specially species adapted in non-friendly environments, produce secondary metabolites that help them to cope with biotic or abiotic stresses. These metabolites could be of great pharmaceutical interest because several of those show cytotoxic, antibacterial or antioxidant activities. Leaves' trichomes of Cistus creticus ssp. creticus, a Mediterranean xerophytic shrub, excrete a resin rich in several labdane-type diterpenes with verified in vitro and in vivo cytotoxic and cytostatic activity against human cancer cell lines. Bearing in mind the properties and possible future exploitation of these natural products, it seemed interesting to study their biosynthesis and its regulation, initially at the molecular level. For this purpose, genes encoding enzymes participating in the early steps of the terpenoids biosynthetic pathways were isolated and their gene expression patterns were investigated in different organs and in response to various stresses and defence signals. The genes studied were the CcHMGR from the mevalonate pathway, CcDXS and CcDXR from the methylerythritol 4-phosphate pathway and the two geranylgeranyl diphosphate synthases (CcGGDPS1 and 2) previously characterized from this species. The present work indicates that the leaf trichomes are very active biosynthetically as far as it concerns terpenoids biosynthesis, and the terpenoid production from this tissue seems to be transcriptionally regulated. Moreover, the CcHMGR and CcDXS genes (the rate-limiting steps of the isoprenoids' pathways) showed an increase during mechanical wounding and application of defence signals (like meJA and SA), which is possible to reflect an increased need of the plant tissues for the corresponding metabolites.
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