ArticleThe American journal of pathology2010
Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 42 citations in OpenAlex.
- Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies.Molecular pharmacology · 2021Article
- The effects of vitamin B12 deficiency on retina and optic disk vascular density.International ophthalmology · 2021Article
- Dissecting the Pathogenesis of Diabetic Retinopathy Based on the Biological ceRNA Network and Genome Variation Disturbance.Computational and mathematical methods in medicine · 2021Article
- Relevance of Peptide Homeostasis in Metabolic Retinal Degenerative Disorders: Curative Potential in Genetically Modified Mice.Frontiers in pharmacology · 2021Review
- Review
- Hydrogen sulfide serves as a biomarker in the anterior segment of patients with diabetic retinopathy.International ophthalmology · 2020Article
- Up-regulated microRNA-199b-3p represses the apoptosis of cerebral microvascular endothelial cells in ischemic stroke through down-regulation of MAPK/ERK/EGR1 axis.Cell cycle (Georgetown, Tex.) · 2019Article
- Subendothelial matrix components influence endothelial cell apoptosis in vitro.American journal of physiology. Cell physiology · 2019Article
- Homocysteine: A Potential Biomarker for Diabetic Retinopathy.Journal of clinical medicine · 2019Article
- Human decidua basalis mesenchymal stem/stromal cells protect endothelial cell functions from oxidative stress induced by hydrogen peroxide and monocytes.Stem cell research & therapy · 2018Article
- Human chorionic villous mesenchymal stem/stromal cells protect endothelial cells from injury induced by high level of glucose.Stem cell research & therapy · 2018Article
- MicroRNA-27a protects retinal pigment epithelial cells under high glucose conditions by targeting TLR4.Experimental and therapeutic medicine · 2018Article
- Nutrition for diabetic retinopathy: plummeting the inevitable threat of diabetic vision loss.European journal of nutrition · 2017Review
- Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes.Investigative ophthalmology & visual science · 2016Article
- Neurodegeneration and Neuroinflammation in Diabetic Retinopathy: Potential Approaches to Delay Neuronal Loss.Current neuropharmacology · 2016Review
- Increased serum level of homocysteine correlates with retinal nerve fiber layer thinning in diabetic retinopathy.Molecular vision · 2016Article
- Systemic Retinaldehyde Treatment Corrects Retinal Oxidative Stress, Rod Dysfunction, and Impaired Visual Performance in Diabetic Mice.Investigative ophthalmology & visual science · 2015Article
- Retinylamine Benefits Early Diabetic Retinopathy in Mice.The Journal of biological chemistry · 2015Article
- Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- miR-15b/16 protects primary human retinal microvascular endothelial cells against hyperglycemia-induced increases in tumor necrosis factor alpha and suppressor of cytokine signaling 3.Journal of neuroinflammation · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Recent studies on the pathogenesis of diabetic retinopathy have focused on correcting adverse biochemical alterations, but there have been fewer efforts to enhance prosurvival pathways. Bcl-2 is the archetypal member of a group of antiapoptotic proteins. In this study, we investigated the ability of overexpressing Bcl-2 in vascular endothelium to protect against early stages of diabetic retinopathy. Transgenic mice overexpressing Bcl-2 regulated by the pre-proendothelin promoter were generated, resulting in increased endothelial Bcl-2. Diabetes was induced with streptozotocin, and mice were sacrificed at 2 months of study to measure superoxide generation, leukostasis, and immunohistochemistry, and at 7 months to assess retinal histopathology. Diabetes of 2 months duration caused a significant decrease in expression of Bcl-2 in retina, upregulation of Bax in whole retina and isolated retinal microvessels, and increased generation of retinal superoxide and leukostasis. Seven months of diabetes caused a significant increase in the number of degenerate (acellular) capillaries in diabetic animals. Furthermore, overexpression of Bcl-2 in the vascular endothelium inhibited the diabetes-induced degeneration of retinal capillaries and aberrant superoxide generation, but had no effect on Bax expression or leukostasis. Therefore, overexpression of Bcl-2 in endothelial cells inhibits the capillary degeneration that is characteristic of the early stages of diabetic retinopathy, and this effect seems likely to involve inhibition of oxidative stress.
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