Trial reportChest2010
Predictors of time to death after terminal withdrawal of mechanical ventilation in the ICU.
Trial report in Chest, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Effectiveness of an Algorithmic Approach to Ventilator Withdrawal at the End of Life: A Stepped Wedge Cluster Randomized Trial.Journal of palliative medicine · 2024Trial
- Palliative extubation in intensive care units: scoping review.Revista da Escola de Enfermagem da U S P · 2026Article
- Palliative General Anesthesia at Terminal Extubation: "Go Gentle into that Good Night".Neurocritical care · 2025Article
- Visiting a loved one in the ICU with the aid of dedicated booklets is associated with reduced separation anxiety in children and adolescents.Child and adolescent psychiatry and mental health · 2025Article
- Palliative extubation experience in a community hospital in southern Brazil.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Breaking bad news in the era of artificial intelligence and algorithmic medicine: an exploration of disclosure and its ethical justification using the hedonic calculus.AI and ethics · 2022Article
- Predicting Time to Death After Withdrawal of Life-Sustaining Treatment in Children.Critical care explorations · 2022Review
- Evolution of Investigating Informed Assent Discussions about CPR in Seriously Ill Patients.Journal of pain and symptom management · 2022Article
- Emotional impact of compassionate extubation on respiratory therapists and nurses: A pilot study.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2022Article
- Death, unity, and the brain.Theoretical medicine and bioethics · 2019Article
- Predictors of withdrawal of life support after burn injury.Burns : journal of the International Society for Burn Injuries · 2019Article
- Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit.Intensive care medicine · 2018Article
- A few realistic questions raised by organ retrieval in the intensive care unit.Annals of translational medicine · 2017Review
- Outcomes following out-of-hospital cardiac arrest: What is the potential for donation after circulatory death?Journal of the Intensive Care Society · 2016Article
- Time to Death after Terminal Withdrawal of Mechanical Ventilation: Specific Respiratory and Physiologic Parameters May Inform Physician Predictions.Journal of palliative medicine · 2015Observational
- Predicting time to death after withdrawal of life-sustaining therapy.Intensive care medicine · 2015Review
- Eligibility for organ donation following end-of-life decisions: a study performed in 43 French intensive care units.Intensive care medicine · 2014Observational
- Factors associated with palliative withdrawal of mechanical ventilation and time to death after withdrawal.Journal of palliative medicine · 2013Article
- Nighttime intensivist staffing and the timing of death among ICU decedents: a retrospective cohort study.Critical care (London, England) · 2013Article
- Mechanical ventilation withdrawal as a palliative procedure in a Brazilian intensive care unit.Revista Brasileira de terapia intensivaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundLittle information exists about the expected time to death after terminal withdrawal of mechanical ventilation. We sought to determine the independent predictors of time to death after withdrawal of mechanical ventilation.
methodsWe conducted a secondary analysis from a cluster randomized trial of an end-of-life care intervention. We studied 1,505 adult patients in 14 hospitals in Washington State who died within or shortly after discharge from an ICU following terminal withdrawal of mechanical ventilation (August 2003 to February 2008). Time to death and its predictors were abstracted from the patients' charts and death certificates. Predictors included demographics, proxies of severity of illness, life-sustaining therapies, and International Classification of Diseases, 9th ed., Clinical Modification codes.
resultsThe median (interquartile range [IQR]) age of the cohort was 71 years (58-80 years), and 44% were women. The median (IQR) time to death after withdrawal of ventilation was 0.93 hours (0.25-5.5 hours). Using Cox regression, the independent predictors of a shorter time to death were nonwhite race (hazard ratio [HR], 1.17; 95% CI, 1.01-1.35), number of organ failures (per-organ HR, 1.11; 95% CI, 1.04-1.19), vasopressors (HR, 1.67; 95% CI, 1.49-1.88), IV fluids (HR, 1.16; 95% CI, 1.01-1.32), and surgical vs medical service (HR, 1.29; 95% CI, 1.06-1.56). Predictors of longer time to death were older age (per-decade HR, 0.95; 95% CI, 0.90-0.99) and female sex (HR, 0.86; 95% CI, 0.77-0.97).
conclusionsTime to death after withdrawal of mechanical ventilation varies widely, yet the majority of patients die within 24 hours. Subsequent validation of these predictors may help to inform family counseling at the end of life.
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What OpenQuestion holds
Registered trials
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