ArticleApplied and environmental microbiology2010
Bacterial capture by peptide-mimetic oligoacyllysine surfaces.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Multifunctional Composite Hydrogels for Bacterial Capture, Growth/Elimination, and Sensing Applications.ACS applied materials & interfaces · 2022Review
- Dimeric γ-AApeptides With Potent and Selective Antibacterial Activity.Frontiers in chemistry · 2020Article
- Using Positively Charged Magnetic Nanoparticles to Capture Bacteria at Ultralow Concentration.Nanoscale research letters · 2019Article
- β-Defensins in the Fight against Helicobacter pylori.Molecules (Basel, Switzerland) · 2017Review
- Improved bacterial detection using immobilized acyl-lysyl oligomers.Applied and environmental microbiology · 2015Article
- Evolution of antimicrobial peptides to self-assembled peptides for biomaterial applications.Pathogens (Basel, Switzerland) · 2014Review
- Nontraditional therapies to treat Helicobacter pylori infection.Journal of microbiology (Seoul, Korea) · 2014Review
- Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?International journal of antimicrobial agents · 2011Review
- Beyond natural antimicrobial peptides: multimeric peptides and other peptidomimetic approaches.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most procedures for detecting pathogens in liquid media require an initial concentration step. However, poor recovery efficiencies of conventional methods, such as filtration, often lead to low sensitivity. Here, we describe a strategy for concentrating bacteria using their binding affinity for an oligoacyllysine (OAK), a novel peptide-mimetic antimicrobial compound. We show that the resin-linked OAK (ROAK) efficiently captures a variety of pathogens in different media, upon brief incubation with ROAK beads or after continuous flow through a ROAK-packed column. Using Escherichia coli expressing green fluorescent protein, we show that binding occurs rapidly during incubation and persists after filtration as visualized by confocal microscopy. The high binding affinity of bacteria was confirmed by surface plasmon resonance technology using an OAK-linked chip. ROAK-bound bacteria remained viable and were readily identifiable by real-time PCR after ethanol elution. A single ROAK bead is estimated to capture about 3,000 bacterial cells in culture medium, in contaminated saline or tap water. ROAK beads can be regenerated for multiple uses after brief ethanol treatment. Collectively, the data support the notion that OAK-based coating of polymeric surfaces might represent a useful means for medium filtration as well as for concentration of bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.