ArticleThe Plant cell2010
Identification of specific DNA binding residues in the TCP family of transcription factors in Arabidopsis.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed, 149 citations in OpenAlex.
- 'Candidatus Liberibacter Asiaticus' Effector SECP8 Subverts Salicylic Acid-Mediated Citrus Immunity via a Two-Pronged Impairment of CsTCP15 Dimerization.Plant biotechnology journal · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- Is Genetic Differentiation Involved in the Morphological Adaptation ofEcology and evolution · 2025Article
- Genome-wide identification and expression analysis of thePhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Article
- JAG modulates sepal flatness by regulating cell growth direction, interacts with AS2, and is antagonized by TCP24.Cell reports · 2025Article
- Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity.Molecular plant · 2025Article
- Many transcription factor families have evolutionarily conserved binding motifs in plants.Plant physiology · 2025Article
- TCP3 is a substrate of the COP1/SPA ubiquitin ligase to regulate anthocyanin accumulation and flowering time inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Overexpression ofPlants (Basel, Switzerland) · 2025Article
- Evolution and comparison of the expression of TCP genes in the benincaseae and cucurbiteae tribes.Scientific reports · 2025Article
- The CIN-TCP transcription factors regulate endocycle progression and pavement cell size by promoting cell wall pectin degradation.Nature communications · 2025Article
- Systematic Analysis of thePlants (Basel, Switzerland) · 2025Article
- Genome-wide analysis of TCP family genes and their constitutive expression pattern analysis in the melon (Cucumis melo).Genes & genomics · 2025Article
- Genome-Wide Identification and Expression Analysis ofInternational journal of molecular sciences · 2025Article
- Identification and expression responses of TCP gene family inFrontiers in plant science · 2025Article
- Unveiling kiwifruit TCP genes: evolution, functions, and expression insights.Plant signaling & behavior · 2024Article
- Heterologous Expression of Chrysanthemum TCP Transcription Factor CmTCP13 Enhances Salinity Tolerance inPlants (Basel, Switzerland) · 2024Article
- Genome-wide identification of TCP transcription factors and their potential roles in hydrolyzable tannin production inFrontiers in plant science · 2024Article
- A double-negative feedback loop between miR319c and JAW-TCPs establishes growth pattern in incipient leaf primordia in Arabidopsis thaliana.PLoS genetics · 2023Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TCP transcription factors control multiple developmental traits in diverse plant species. Members of this family share an approximately 60-residue-long TCP domain that binds to DNA. The TCP domain is predicted to form a basic helix-loop-helix (bHLH) structure but shares little sequence similarity with canonical bHLH domain. This classifies the TCP domain as a novel class of DNA binding domain specific to the plant kingdom. Little is known about how the TCP domain interacts with its target DNA. We report biochemical characterization and DNA binding properties of a TCP member in Arabidopsis thaliana, TCP4. We have shown that the 58-residue domain of TCP4 is essential and sufficient for binding to DNA and possesses DNA binding parameters comparable to canonical bHLH proteins. Using a yeast-based random mutagenesis screen and site-directed mutants, we identified the residues important for DNA binding and dimer formation. Mutants defective in binding and dimerization failed to rescue the phenotype of an Arabidopsis line lacking the endogenous TCP4 activity. By combining structure prediction, functional characterization of the mutants, and molecular modeling, we suggest a possible DNA binding mechanism for this class of transcription factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.