ReviewSeminars in cell & developmental biology2010
Metabolic manipulation of glycosylation disorders in humans and animal models.
Review in Seminars in cell & developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Metabolome Wide Mendelian Randomization Assessing the Causal Relationship Between Serum Metabolites, Cerebrospinal Metabolites, and Aneurysmal Subarachnoid Hemorrhage.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Computational studies on the functional and structural impact of pathogenic mutations in enzymes.Protein science : a publication of the Protein Society · 2025Review
- N-glycosylation, a leading role in viral infection and immunity development.Molecular biology reports · 2022Review
- A roadmap for translational cancer glycoimmunology at single cell resolution.Journal of experimental & clinical cancer research : CR · 2022Review
- Mannose: A Sweet Option in the Treatment of Cancer and Inflammation.Frontiers in pharmacology · 2022Review
- Mannose Treatment: A Promising Novel Strategy to Suppress Inflammation.Frontiers in immunology · 2021Review
- Unveiling the metabolic fate of monosaccharides in cell membranes with glycomic and glycoproteomic analyses.Chemical science · 2019Article
- Health effects of kiwi wine on rats: an untargeted metabolic fingerprint study based on GC-MS/TOF.RSC advances · 2019Article
- The role of post-translational modifications in hearing and deafness.Cellular and molecular life sciences : CMLS · 2016Review
- Mannose metabolism: more than meets the eye.Biochemical and biophysical research communications · 2014Review
- N-glycosylation deficiency reduces ICAM-1 induction and impairs inflammatory response.Glycobiology · 2014Article
- Solving glycosylation disorders: fundamental approaches reveal complicated pathways.American journal of human genetics · 2014Review
- A novel congenital disorder of glycosylation type without central nervous system involvement caused by mutations in the phosphoglucomutase 1 gene.Journal of inherited metabolic disease · 2013Article
- Understanding human glycosylation disorders: biochemistry leads the charge.The Journal of biological chemistry · 2013Review
- New horizons for congenital myasthenic syndromes.Annals of the New York Academy of Sciences · 2012Review
- The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter.The Journal of biological chemistry · 2012Article
- Posttranslational modifications in connexins and pannexins.The Journal of membrane biology · 2012Review
- Identification of intercellular cell adhesion molecule 1 (ICAM-1) as a hypoglycosylation marker in congenital disorders of glycosylation cells.The Journal of biological chemistry · 2012Article
- Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts.The Journal of biological chemistry · 2011Article
- Mouse models for congenital disorders of glycosylation.Journal of inherited metabolic disease · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In the last decade, over 40 inherited human glycosylation disorders were identified. Most patients have hypomorphic, rather than null alleles. The phenotypic spectrum is broad and most of the disorders affect embryonic and early post-natal development; a few appear in adult life. Some deficiencies can be treated with simple dietary sugar (monosaccharide) supplements. Here we focus on four glycosylation disorders that have been treated with supplements in patients or in model systems, primarily the mouse. Surprisingly, small differences in the amount of exogenous sugar have a major impact on the diseases in specific cells or organs while others are unaffected. The underlying mechanisms are mostly unknown, but changes in the contributions of the de novo, salvage and dietary pathways may contribute to the beneficial outcome. Clearly, the metabolic chart is not flat; all arrows are not equally robust at all points of time and space. This metabolic perspective may help explain some of these observations and guide the development of other vertebrate models of glycosylation disorders that can respond to dietary manipulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.