SynthesisNeurobiology of aging2012
Heritability of brain ventricle volume: converging evidence from inconsistent results.
Synthesis in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.Nature communications · 2018Pooled it
- Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group.Human brain mapping · 2017Pooled it
- Evans' Index and Frontal and Occipital Horn Ratio in Correlation to Volumetric Data of Lateral Ventricles in a Population-based MRI Study.Clinical neuroradiology · 2026Article
- Fetal mri of obstructive hydrocephalus: a review proposing a surgical etiology-based approach.Neuroradiology · 2026Review
- Twin differences in lateral ventricle size accompany twin differences in phonological decoding.Brain structure & function · 2025Article
- DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Genetic architecture of Alzheimer's disease.Neurobiology of disease · 2020Review
- Genome-wide association study identifiesAging · 2019Article
- NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis.Translational psychiatry · 2019Article
- A polygenic risk score analysis of psychosis endophenotypes across brain functional, structural, and cognitive domains.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2018Article
- White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure.NeuroImage. Clinical · 2016Article
- Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use.Behavior genetics · 2015Article
- Studying ventricular abnormalities in mild cognitive impairment with hyperbolic Ricci flow and tensor-based morphometry.NeuroImage · 2015Article
- The ventricular system of the brain: a comprehensive review of its history, anatomy, histology, embryology, and surgical considerations.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Review
- Article
- Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Morphometric abnormalities of the lateral ventricles in methamphetamine-dependent subjects.Drug and alcohol dependence · 2013Article
- Mapping the genetic variation of regional brain volumes as explained by all common SNPs from the ADNI study.PloS one · 2013Article
- Genetic architecture of context processing in late middle age: more than one underlying mechanism.Psychology and aging · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Twin studies generally show great consistency for the heritability of brain structures. Ironically, the lateral ventricles--perhaps the most reliably measured brain regions of interest--are the most inconsistent when it comes to estimating genetic influences on their volume. Heritability estimates in twin studies have ranged from zero to almost 0.80. Here we aggregate heritability estimates from extant twin studies, and we review and reinterpret some of the findings. Based on our revised estimates, we conclude that lateral ventricular volume is indeed heritable. The weighted average heritability of the revised estimates was 0.54. Although accumulated environmental insults might seem most logical as the predominant cause of age-related ventricular expansion, the data strongly suggest that genetic influences on lateral ventricular volume are increasing with age. Genetic influences accounted for 32-35% of the variance in lateral ventricular volume in childhood, but about 75% of the variance in late middle and older age. These conclusions have implications for the basic understanding of the genetic and environmental underpinnings of normative and pathological brain aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.