ArticleNeurobiology of aging2012
Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers, 1 of them a synthesis that pooled it.
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Who cites it
168 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcranial direct current stimulation for global cognition in Alzheimer's disease: a systemic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Trial
- Diffusion spectrum imaging in white matter microstructure in subjects with type 2 diabetes.PloS one · 2018Trial
- The relevance of short-range fibers to cognitive efficiency and brain activation in aging and dementia.PloS one · 2014Trial
- White matter hyperintensities, exercise, and improvement in gait speed: does type of gait rehabilitation matter?Journal of the American Geriatrics Society · 2013Trial
- The role of corpus callosum development in functional connectivity and cognitive processing.PloS one · 2012Trial
- Divergent Multimodal Age-Association Profiles Across the Human Brain.Nature communications · 2026Article
- A Multimodal MRI Study of the White Matter Microstructural and Hemodynamic Underpinnings of Cognitive Decline in Type 2 Diabetes Mellitus.Brain topography · 2026Article
- Sex differences in diffusion-weighted imaging outcomes in autosomal dominant Alzheimer's disease.Brain communications · 2026Article
- The relationship between racial discrimination and white matter among Black older adults.Neurobiology of aging · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi-Ethnic Study of Atherosclerosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Clinical Improvement after Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus Can Be Quantified by Diffusion Tensor Imaging.AJNR. American journal of neuroradiology · 2025Article
- Temporal changes and implications of diffusion tensor imaging metrics and cerebral white matter volume in patients undergoing carotid endarterectomy - a prospective study.Neuroradiology · 2025Article
- Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.Human brain mapping · 2024Article
- Article
- Spatiotemporal Patterns of White Matter Maturation after Pre-Adolescence: A Diffusion Kurtosis Imaging Study.Brain sciences · 2024Article
- Genetic architecture of the structural connectome.Nature communications · 2024Article
- Impact of white matter hyperintensities on structural connectivity and cognition in cognitively intact ADNI participants.Neurobiology of aging · 2024Article
- Investigating the effect of hypertension on vascular cognitive impairment by using the resting-state functional connectome.Scientific reports · 2024Article
108 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Age-related decline in microstructural integrity of certain white matter tracts may explain cognitive decline associated with normal aging. Whole brain tractography and a clustering segmentation in 48 healthy individuals across the adult lifespan were used to examine: interhemispheric (corpus callosum), intrahemispheric association (cingulum, uncinate, arcuate, inferior longitudinal, inferior occipitofrontal), and projection (corticospinal) fibers. Principal components analysis reduced cognitive tests into 6 meaningful factors: (1) memory and executive function; (2) visuomotor dexterity; (3) motor speed; (4) attention and working memory; (5) set-shifting/flexibility; and (6) visuospatial construction. Using theory-based structural equation modeling, relationships among age, white matter tract integrity, and cognitive performance were investigated. Parsimonious model fit demonstrated relationships where decline in white matter integrity may explain age-related decline in cognitive performance: inferior longitudinal fasciculus (ILF) with visuomotor dexterity; the inferior occipitofrontal fasciculus with visuospatial construction; and posterior fibers (i.e., splenium) of the corpus callosum with memory and executive function. Our findings suggest that decline in the microstructural integrity of white matter fibers can account for cognitive decline in normal aging.
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