ArticleNeuroImage2011
Grey matter and cognitive deficits in young relatives of schizophrenia patients.
Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Heritability of Neuropsychological Measures in Schizophrenia and Nonpsychiatric Populations: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2017Pooled it
- Differential expression of diacylglycerol kinase ζ is involved in inferior parietal lobule-related dysfunction in schizophrenia with cognitive impairments.BMC psychiatry · 2023Article
- Déjà-vu? Neural and behavioural effects of the 5-HTTranslational psychiatry · 2021Article
- A comparison of cognitive performance in the Suffolk County cohort and their unaffected siblings.Psychiatry research · 2021Article
- Brain Functional Connectivity Changes in Patients with Acute Eye Pain: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Differences in executive function among patients with schizophrenia, their unaffected first-degree relatives and healthy participants.The international journal of neuropsychopharmacology · 2020Article
- A Prospective Longitudinal Investigation of Cortical Thickness and Gyrification in Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Machine learning identifies unaffected first-degree relatives with functional network patterns and cognitive impairment similar to those of schizophrenia patients.Human brain mapping · 2019Article
- Structural and Functional Neuroimaging of Polygenic Risk for Schizophrenia: A Recall-by-Genotype-Based Approach.Schizophrenia bulletin · 2019Article
- Shared Genetic Risk of Schizophrenia and Gray Matter Reduction in 6p22.1.Schizophrenia bulletin · 2019Article
- Gyrification Connectomes in Unmedicated Patients With Schizophrenia and Following a Short Course of Antipsychotic Drug Treatment.Frontiers in psychiatry · 2018Article
- Disruptions in the left frontoparietal network underlie resting state endophenotypic markers in schizophrenia.Human brain mapping · 2017Article
- Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia.Molecular psychiatry · 2016Article
- Polymorphisms in MIR137HG and microRNA-137-regulated genes influence gray matter structure in schizophrenia.Translational psychiatry · 2016Article
- Selective functional connectivity abnormality of the transition zone of the inferior parietal lobule in schizophrenia.NeuroImage. Clinical · 2016Article
- Alterations of lateral temporal cortical gray matter and facial memory as vulnerability indicators for schizophrenia: An MRI study in youth at familial high-risk for schizophrenia.Schizophrenia research · 2016Article
- Hippocampal volume is reduced in schizophrenia and schizoaffective disorder but not in psychotic bipolar I disorder demonstrated by both manual tracing and automated parcellation (FreeSurfer).Schizophrenia bulletin · 2015Article
- Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia.The international journal of neuropsychopharmacology · 2014Article
- Biomarkers and clinical staging in psychiatry.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2014Article
- Relationship between prefrontal gray matter volumes and working memory performance in schizophrenia: a family study.Schizophrenia research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Grey-matter volumetric and cognitive deficits in young, high-risk relatives of schizophrenia patients may be vulnerability markers of the illness. Although these markers may be correlated, it is unclear if their distributions in relatives overlap. We examined convergence of these markers in 94 young first and second-degree relatives (HR) and 81 healthy controls. Subjects were assessed using WCST, CPT-IP and Benton-Hamscher tests and on grey-matter volumes of brain regions related to language, attention and executive function using FreeSurfer to process T1-MR-images. K-means clustering using cognitive performance scores split relatives into sub-samples with better (HR+C, n=35) and worse (HR-C, n=59) cognition after controlling for age and gender. All regional volumes and language related regional laterality-indices were compared between HR-C, HR+C and control subjects, controlling for age, gender and intra-cranial volume. Volumes of caudate nuclei, thalami, hippocampi, inferior frontal gyri, Heschl's gyri, superior parietal cortices, supramarginal gyri, right angular gyrus, right middle frontal gyrus and right superior frontal gyrus, leftward laterality of supramarginal and inferior frontal gyri and rightward laterality of the angular gyrus were reduced in HR-C compared to controls. Volumes of Heschl's gyri, left supramarginal gyrus, inferior frontal gyri, hippocampi and caudate nuclei HR-C were smaller in HR-C compared to HR+C. HR+C showed deficits compared to controls only for the superior parietal and right angular volumes. Premorbid neuroanatomical and laterality alterations in schizophrenia may selectively manifest in cognitively compromised relatives. Overlapping structural and cognitive deficits may define a hyper vulnerable sub-sample among individuals at familial predisposition to schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.