ArticleCell stem cell2010
Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells.
Article in Cell stem cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA.Nature communications · 2024Article
- Article
- Lineage tracing: technology tool for exploring the development, regeneration, and disease of the digestive system.Stem cell research & therapy · 2020Review
- In vivo studies of glucagon secretion by human islets transplanted in mice.Nature metabolism · 2020Article
- Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards.Nature communications · 2020Article
- A critical look: Challenges in differentiating human pluripotent stem cells into desired cell types and organoids.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Molecular and genetic regulation of pig pancreatic islet cell development.Development (Cambridge, England) · 2020Article
- Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions.Cell death & disease · 2019Article
- A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas.Cell systems · 2018Article
- Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors.Developmental cell · 2017Article
- Article
- Article
- The lncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression.Cell reports · 2015Article
- Quantitative Raman spectral changes of the differentiation of mesenchymal stem cells into islet-like cells by biochemical component analysis and multiple peak fitting.Journal of biomedical optics · 2015Article
- Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells.Cell research · 2014Article
- An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development.PLoS genetics · 2014Article
- Transcriptional control of mammalian pancreas organogenesis.Cellular and molecular life sciences : CMLS · 2014Review
- Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?Reproduction (Cambridge, England) · 2014Article
- Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations.Cell stem cell · 2014Article
- Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA.Developmental biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
There is considerable excitement about harnessing the potential of human stem cells to replace pancreatic islets that are destroyed in type 1 diabetes mellitus. However, our current understanding of the mechanisms underlying pancreas and islet ontogeny has come largely from the powerful genetic, developmental, and embryological approaches available in nonhuman organisms. Successful islet reconstruction from human pluripotent cells will require greater attention to "deconstructing" human pancreas and islet developmental biology and consistent application of conditional genetics, lineage tracing, and cell purification to stem cell biology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.