ArticleBlood cells, molecules & diseases2010
TEThered to Runx: novel binding partners for runx factors.
Article in Blood cells, molecules & diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.Structure (London, England : 1993) · 2021Article
- Article
- Fused in Sarcoma: Properties, Self-Assembly and Correlation with Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2019Review
- Energy Homeostasis and Abnormal RNA Metabolism in Amyotrophic Lateral Sclerosis.Frontiers in cellular neuroscience · 2017Review
- Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants.The EMBO journal · 2016Article
- Initial Characterization of Osteoblast Differentiation and Loss of RUNX2 Stability in the Newly Established SK11 Human Embryonic Stem Cell-Derived Cell Line.Journal of cellular physiology · 2015Article
- Glucocorticoid-Induced Osteoporosis.Advances in experimental medicine and biology · 2015Review
- RUNX3 facilitates growth of Ewing sarcoma cells.Journal of cellular physiology · 2014Article
- Knockdown of PRKAR1A, the gene responsible for Carney complex, interferes with differentiation in osteoblastic cells.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Activation of HIV-1 from latent infection via synergy of RUNX1 inhibitor Ro5-3335 and SAHA.PLoS pathogens · 2014Article
- The bone-specific Runx2-P1 promoter displays conserved three-dimensional chromatin structure with the syntenic Supt3h promoter.Nucleic acids research · 2014Article
- ODAM Expression Inhibits Human Breast Cancer Tumorigenesis.Breast cancer : basic and clinical research · 2011Article
- Article
- The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation.Journal of cellular biochemistry · 2010Article
- TDP-43/FUS in motor neuron disease: Complexity and challenges.Progress in neurobiologyReview
- RUNX2 Represses the EWS-FLI1-mediated Transcription in Ewing's Sarcoma Cells.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
RUNX transcription factors reside in the nuclear matrix where they integrate numerous signaling pathways to regulate gene expression and affect tissue development, regeneration, and tumorigenesis. An affinity purification and proteomic experiment was performed to identify novel Runx2 binding partners. The interactions between Runx2 and two nuclear factors (Ddx5 and CoAA) identified in this screen were previously described. Coactivator activator (CoAA) bound the DNA binding domain of Runx2 and prevented Runx-driven gene expression. The YxxQ motif in CoAA was required for Runx2 interactions. Members of the FET/TET family of proteins, including FUS/TLS and EWSR1, contain a similar motif and were hypothesized to interact with Runx2. Here, we provide evidence that FUS/TLS, EWSR1, and the Ewing's sarcoma t(12;21) fusion protein EWS-FLI bind Runx2 and alter its transcriptional activity. Potential roles of protein complexes containing FET/TET and RUNX family members during tumor formation and mesenchymal progenitor cell differentiation are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.