ArticleCurrent biology : CB2010
DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
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Who cites it
104 citing papers in PubMed.
- Metaplastic sleep regulation inbioRxiv : the preprint server for biology · 2026Article
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- A functional clock in only two dorsal clock neurons is sufficient to restore the basal circadian activity pattern ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neuropeptide dynamics coordinate layered plasticity mechanisms adaptingScience advances · 2025Article
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- Dynamic neuronal instability generates synaptic plasticity and behavior: Insights from Drosophila sleep.Neuroscience research · 2024Review
- Towards improving the prognosis of stroke through targeting the circadian clock system.International journal of biological sciences · 2024Review
- Molecular and Neural Mechanisms of Temperature Preference Rhythm inJournal of biological rhythms · 2023Review
- Dissecting neuron-specific functions of circadian genes using modified cell-specific CRISPR approaches.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Organismal landscape of clock cells and circadian gene expression inbioRxiv : the preprint server for biology · 2023Article
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- miR-277 regulates the phase of circadian activity-rest rhythm inFrontiers in physiology · 2023Article
- Circadian rhythm as a key player in cancer progression as well as a therapeutic target inFrontiers in oncology · 2023Review
- Light triggers a network switch between circadian morning and evening oscillators controlling behaviour during daily temperature cycles.PLoS genetics · 2022Article
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- Ubiquitin proteasome system in circadian rhythm and sleep homeostasis: Lessons from Drosophila.Genes to cells : devoted to molecular & cellular mechanisms · 2022Review
- Dorsal clock networks drive temperature preference rhythms in Drosophila.Cell reports · 2022Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
Abstract
backgroundDaily behaviors in animals are determined by the interplay between internal timing signals from circadian clocks and environmental stimuli such as light. How these signals are integrated to produce timely and adaptive behavior is unclear. The fruit fly Drosophila exhibits clock-driven activity increases that anticipate dawn and dusk and free-running rhythms under constant conditions. Flies also respond to the onset of light and dark with acute increases in activity.
resultsMutants of a novel ion channel, narrow abdomen (na), lack a robust increase in activity in response to light and show reduced anticipatory behavior and free-running rhythms, providing a genetic link between photic responses and circadian clock function. We used tissue-specific rescue of na to demonstrate a role for approximately 16-20 circadian pacemaker neurons, a subset of the posterior dorsal neurons 1 (DN1(p)s), in mediating the acute response to the onset of light as well as morning anticipatory behavior. Circadian pacemaker neurons expressing the neuropeptide PIGMENT-DISPERSING FACTOR (PDF) are especially important for morning anticipation and free-running rhythms and send projections to the DN1(p)s. We also demonstrate that DN1(p)Pdfr expression is sufficient to rescue, at least partially, Pdfr morning anticipation defects as well as defects in free-running rhythms, including those in DN1 molecular clocks. Additionally, these DN1 clocks in wild-type flies are more strongly reset to timing changes in PDF clocks than other pacemaker neurons, suggesting that they are direct targets.
conclusionsTaking these results together, we demonstrate that the DN1(p)s lie at the nexus of PDF and photic signaling to produce appropriate daily behavior.
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