ArticleCurrent biology : CB2010
Electrical control of cell polarization in the fission yeast Schizosaccharomyces pombe.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
- Particle-based simulations reveal two positive feedback loops allow relocation and stabilization of the polarity site during yeast mating.PLoS computational biology · 2023Article
- Electrotaxis-on-Chip to Quantify Neutrophil Migration Towards Electrochemical Gradients.Frontiers in immunology · 2021Article
- Ammonium transceptors: Novel regulators of fungal development.PLoS pathogens · 2019Article
- Planarian regeneration as a model of anatomical homeostasis: Recent progress in biophysical and computational approaches.Seminars in cell & developmental biology · 2019Review
- Electric field-induced migration and intercellular stress alignment in a collective epithelial monolayer.Molecular biology of the cell · 2018Article
- Electric fields accelerate cell polarization and bypass myosin action in motility initiation.Journal of cellular physiology · 2018Article
- Spermine modulates fungal morphogenesis and activates plasma membrane HBiology open · 2018Article
- Bioelectric signaling in regeneration: Mechanisms of ionic controls of growth and form.Developmental biology · 2018Review
- Studying Electrotaxis in Microfluidic Devices.Sensors (Basel, Switzerland) · 2017Review
- Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form.Annual review of biomedical engineering · 2017Review
- Article
- Spontaneous and electric field-controlled front-rear polarization of human keratinocytes.Molecular biology of the cell · 2015Article
- Wall mechanics and exocytosis define the shape of growth domains in fission yeast.Nature communications · 2015Article
- KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.Nature communications · 2015Article
- Oscillatory AAA+ ATPase Knk1 constitutes a novel morphogenetic pathway in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Electrochemical regulation of budding yeast polarity.PLoS biology · 2014Article
- Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo.Molecular biology of the cell · 2014Article
- Article
- 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.Analytical chemistry · 2014Article
- Mechanical checkpoint for persistent cell polarization in adhesion-naive fibroblasts.Biophysical journal · 2014Article
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Abstract
Electric signals surround tissues and cells and have been proposed to participate in directing cell polarity in processes such as development, wound healing, and host invasion [1, 2]. The application of exogenous electric fields (EFs) can direct cell polarization in cell types ranging from bacteria and fungi to neurons and neutrophils [3-7]. The mechanisms by which EFs modulate cell polarity, however, remain poorly understood. Here we introduce the fission yeast Schizosaccharomyces pombe as a model organism to elucidate the mechanisms underlying this process. In these rod-shaped cells, an exogenous EF reorients cell growth in a direction orthogonal to the field, producing cells with a bent morphology. A candidate genetic screen identifies conserved factors involved in this process: an integral membrane proton ATPase pma1p that regulates intracellular pH, the small GTPase cdc42p, and the formin for3p that assembles actin cables. Interestingly, mutants in these genes still respond to the EF but orient in a different direction, toward the anode. In addition, EFs also cause electrophoretic movement of cell wall synthase complex proteins toward the anode. These data suggest molecular models for how the EF reorients cell polarization by modulating intracellular pH and steering cell polarity factors in multiple directions.
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