ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2010
Polymorphism in vitamin D receptor is associated with bone mineral density in patients with adolescent idiopathic scoliosis.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Vitamin D in adolescent idiopathic scoliosis: a meta-analysis.BMC musculoskeletal disorders · 2023Pooled it
- Association between polymorphisms in vitamin D receptor gene and adolescent idiopathic scoliosis: a meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2018Pooled it
- Pooled it
- Association between bone mineral density and scoliosis: a two-sample mendelian randomization study in european populations.Hereditas · 2024Article
- Association of IL‑6 and MMP‑3 gene polymorphisms with adolescent idiopathic scoliosis: A systematic review and meta‑analysis.Experimental and therapeutic medicine · 2024Article
- Maternal Age at Menarche Genes Determines Fetal Growth Restriction Risk.International journal of molecular sciences · 2024Article
- Maternal Age at Menarche Gene Polymorphisms Are Associated with Offspring Birth Weight.Life (Basel, Switzerland) · 2023Article
- Back pain in adolescent idiopathic scoliosis: A comprehensive review.Journal of children's orthopaedics · 2023Review
- Risk factors associated with low bone mineral density in children with idiopathic scoliosis: a scoping review.BMC musculoskeletal disorders · 2023Article
- Whole-Exome Sequencing Identifies Genetic Variants for Severe Adolescent Idiopathic Scoliosis in a Taiwanese Population.Journal of personalized medicine · 2022Article
- Age and Spinal Disease Correlate to Albumin and Vitamin D Status.Global spine journal · 2022Article
- Controlling the Progression of Curvature in Children and Adolescent Idiopathic Scoliosis Following the Administration of Melatonin, Calcium, and Vitamin D.Children (Basel, Switzerland) · 2022Article
- Current concepts in the diagnosis and management of adolescent idiopathic scoliosis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Dietary Habits Had No Relationship with Adolescent Idiopathic Scoliosis: Analysis Utilizing Quantitative Data about Dietary Intakes.Nutrients · 2019Article
- Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid ThemJournal of clinical research in pediatric endocrinology · 2019Review
- A histomorphometric study of the cancellous spinal process bone in adolescent idiopathic scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2017Article
- Etiological Theories of Adolescent Idiopathic Scoliosis: Past and Present.The open orthopaedics journal · 2017Review
- Vitamin D receptor gene polymorphism in Egyptian pediatric acute lymphoblastic leukemia correlation with BMD.Meta gene · 2016Review
- Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis.World journal of orthopedics · 2015Article
- Participation of sex hormones in multifactorial pathogenesis of adolescent idiopathic scoliosis.International orthopaedics · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low bone mass and osteopenia have been reported in the axial and peripheral skeleton of adolescent idiopathic scoliosis (AIS) patients. Furthermore, several recent studies have shown that gene polymorphisms are related to osteoporosis. However, no study has yet linked polymorphisms in the vitamin D receptor (VDR) gene and bone mass in AIS. Accordingly, the authors examined the association between bone mass and VDR gene polymorphisms in 198 girls diagnosed with AIS. The VDR BsmI (rs1544410), FokI (rs2228670) and Cdx2 (rs11568820) polymorphisms and bone mineral density at the lumbar spine (LSBMD) and femoral neck (FNBMD) were analyzed and compared to their levels in healthy controls. Mean LSBMD and FNBMD in AIS patients were lower than in age- and sex-matched healthy controls (P = 0.0022 and P = 0.0013, respectively). A comparison of genotype frequencies in AIS patients and controls revealed a significant difference for the BsmI polymorphism only (P = 0.0054). Furthermore, a significant association was found between the VDR BsmI polymorphism and LSBMD. In particular, LSBMD in AIS patients with the AA genotype was found to be significantly lower than in patients with the GA (P < 0.05) or GG (P < 0.01) genotypes. However, no significant association was found between LSBMD or FNBMD and the VDR FokI or Cdx2 polymorphisms. These results suggest that the VDR BsmI polymorphism is associated with LSBMD in girls with AIS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.