ArticleThe open cardiovascular medicine journal2010
Myocardial ischemia in Wegener's granulomatosis: coronary atherosclerosis versus vasculitis.
Article in The open cardiovascular medicine journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Article
- A challenging case of granulomatosis with polyangiitis with cardiac involvement: a rare case report.AME case reports · 2023Article
- Multiple Giant Coronary Artery Aneurysms in a Pediatric Patient with Granulomatosis with Polyangiitis.Pediatric cardiology · 2022Article
- Granulomatous Polyangiitis With Renal Involvement: A Case Report and Review of Literature.Cureus · 2021Article
- Non-traditional risk factors and the risk of myocardial infarction in the young in the US population-based cohort.International journal of cardiology. Heart & vasculature · 2020Article
- Giant Thrombosis at Left Anterior Descending Artery Aneurysm in a 10-Year Old Boy with Granulomatosis with Polyangiitis.Case reports in cardiology · 2020Article
- Endothelial dysfunction in patients with granulomatosis with polyangiitis: a case-control study.Rheumatology international · 2018Article
- Acute Myocardial Infarction in Young Systemic Lupus Erythematosus Patient with Normal Coronary Arteries.Cureus · 2017Article
- Standard and feature tracking magnetic resonance evidence of myocardial involvement in Churg-Strauss syndrome and granulomatosis with polyangiitis (Wegener's) in patients with normal electrocardiograms and transthoracic echocardiography.The international journal of cardiovascular imaging · 2013Article
- Silent Ischemic Heart Disease in a Patient with Necrotizing Glomerulonephritis due to Wegener's Granulomatosis.Cardiorenal medicine · 2012Article
- ST-segment elevation in non-atherosclerotic coronaries: a brief overview.Internal and emergency medicine · 2011Review
- Inflammation, thrombosis and vascular biology: translating ideas into cardiovascular research and therapy.The open cardiovascular medicine journal · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wegener's granulomatosis (WG) is one of the most common small- and medium-sized necrotizing vasculitides that mainly affects the upper and lower respiratory tract and the kidneys. Cardiac manifestations in WG are relatively rare, and their role and place among different causes of mortality remain largely unknown. Substantially increased number of reports describing involvement of all structures of the heart, which underlie conduction disturbances, valvular disease, ischemic heart disease and other potentially serious conditions, underscores importance of comprehensive cardiovascular investigations and monitoring of patients with WG. The majority of previous reports and our current observation distinguish coronary vasculitis and thrombosis as a cause of myocardial ischemia and cardiovascular co-morbidities in WG. It seems plausible that inflammatory processes in this disease, like in some other systemic vasculitidies, do not predispose to accelerated atherogenesis. However, characteristic small- and medium-sized vasculitis still can manifest as myocardial ischemia and infarction. We overview diverse cardiac manifestations and present our own rare case of angina in the oligosymptomatic debut of WG. Importantly, in this case, coronarography failed to reveal atherosclerotic disease or thrombotic occlusion. However, magnetic resonance imaging (MRI) with adenosine test revealed subendocardial ischemia. As a result of immunosuppressive therapy with a steroid and cyclophosphamide, myocardial ischemia disappeared.
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