Evidence map›Paper›PMID 20360544›Full record

ArticleStroke2010

Autopsy findings after intracranial thrombectomy for acute ischemic stroke: a clinicopathologic study of 5 patients.

Nicole S Yin, Sebastian Benavides, Sidney Starkman, David S Liebeskind, Jeffrey A Saver, Noriko Salamon, Reza Jahan, Gary R Duckwiler, Satoshi Tateshima, Fernando Vinuela and 3 more

Open access · bronzeAbstract readCase ReportsComparative Study
In one paragraph

Article in Stroke, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 55 citations in OpenAlex.

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  15. Review
  16. Contrast Extravasation versus Hemorrhage after Thrombectomy in Patients with Acute Stroke.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2017
    Article
  17. Article
  18. What is meant by "TICI"?AJNR. American journal of neuroradiology · 2013
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Nicole S YinDepartment of Pathology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
Sebastian Benavides
Sidney Starkman
David S Liebeskind
Jeffrey A Saver
Noriko Salamon
Reza Jahan
Gary R Duckwiler
Satoshi Tateshima
Fernando Vinuela
Paul M Vespa
Dennis J Chute
Harry V Vinters
Neurology, Inc · US

Funding

UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VINTERS, HARRY V. · 1999 to 2014
$25.9M
UCLA SPOTRIAS CENTER APPLICATION RENEWAL-PROGRAM PROJECTP50NS044378 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAVER, JEFFREY L · 2003 to 2012
$17.2M
Collateral Circulation in Acute Ischemic StrokeK23NS054084 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LIEBESKIND, DAVID SIGMUND · 2006 to 2010
$764k
NIA NIH HHS P50 AG016570NINDS NIH HHS K23 NS054084NINDS NIH HHS P50 NS 044378NINDS NIH HHS P50 NS044378
6 · The paper itself

Abstract

background and purposeEndovascular thrombectomy is an increasingly used treatment for arterial occlusion in acute stroke. Various devices (including most extensively the Mechanical Embolus Removal in Cerebral Ischemia [MERCI] Retriever device) have been used for this.

methodsWe review the neuropathologic findings in 5 patients (age range, 59 to 87 years) who died acutely or as late as 38 days after procedures using the MERCI (4 patients) and Penumbra (1 patient) devices were carried out to remove thromboemboli from the middle cerebral artery. Partial recanalization was achieved by thrombectomy in all 5 patients.

resultsAll patients showed extensive cerebral infarcts, 3 of 5 with clinical hemorrhagic transformations of the infarct or frank intraparenchymal hemorrhage after thrombectomy; in 1 case, this was judged to be at least partly on the basis of concomitant hypertensive microvascular disease. With 1 exception, basal arteries examined in detail by immunohistochemistry showed prominent, although usually nonocclusive (and generally nonulcerated), atheromata, often with significant luminal stenosis. One patient showed a subintimal dissection with resultant occlusion of the middle cerebral artery.

conclusionsIn this highly selected group of patients, the vascular pathological abnormalities affecting basal arteries were variable, but complicated atherosclerosis was a common finding. Extensive irreversible brain necrosis before therapeutic procedures may have contributed to deaths.

Indexed as

ThrombectomyAgedAged, 80 and overBrain IschemiaFemaleHumansIntracranial ThrombosisMaleMiddle AgedStrokeSubarachnoid HemorrhageTissue Plasminogen ActivatorTissue Plasminogen Activator

Identifiers

PMID20360544
PMCPMC4120894
OpenAlexW2117059543

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.