ArticleStroke2010
Coronary artery calcium, brain function and structure: the AGES-Reykjavik Study.
Article in Stroke, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- Pooled it
- The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis.Journal of atherosclerosis and thrombosis · 2020Pooled it
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Prevalence of Brain Microbleeds in Alzheimer Disease: A Systematic Review and Meta-Analysis on the Influence of Neuroimaging Techniques.AJNR. American journal of neuroradiology · 2016Pooled it
- Coronary Artery Calcium and Cognitive Decline in the Diabetes Prevention Program Outcomes Study.Journal of the American Heart Association · 2023Trial
- Subclinical Cardiovascular Disease and Death, Dementia, and Coronary Heart Disease in Patients 80+ Years.Journal of the American College of Cardiology · 2016Trial
- Coronary artery calcium and physical performance as determinants of mortality in older age: the AGES-Reykjavik Study.International journal of cardiology · 2013Trial
- Article
- Coronary artery disease and neurocognitive performance among older adults in Uganda.Research square · 2026Article
- Heart-Brain Axis: Subclinical Cardiovascular Changes and Brain Health.Journal of the American Heart Association · 2026Review
- Multivariate White Matter Microstructure Alterations in Older Adults with Coronary Artery Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Coronary Atherosclerosis and Subclinical Cerebral Small Vessel Disease: A Robust Association Beyond Intracranial Atherosclerosis and Cardiac Systolic Function.Journal of the American Heart Association · 2025Article
- Arterial calcification in the heart-brain axis and cognitive performance over time.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The heart-brain axis: unraveling the interconnections between cardiovascular and Alzheimer's diseases.Frontiers in cardiovascular medicine · 2025Review
- Review
- Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study.Journal of the American Heart Association · 2024Article
- Beyond the Heart: The Predictive Role of Coronary Artery Calcium Scoring in Non-Cardiovascular Disease Risk Stratification.Diagnostics (Basel, Switzerland) · 2024Review
- Atherosclerotic burden and cerebral small vessel disease: exploring the link through microvascular aging and cerebral microhemorrhages.GeroScience · 2024Review
- Risk of Stroke, Dementia, and Cognitive Decline with Coronary and Arterial Calcification.Journal of clinical medicine · 2024Review
- Biological Risk Factors Influencing Vascular Cognitive Impairments: A Review of the Evidence.Brain sciences · 2023Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
background and purposeSeveral cardiovascular risk factors are associated with cognitive disorders in older persons. Little is known about the association of the burden of coronary atherosclerosis with brain structure and function.
methodsThis is a cross-sectional analysis of data from the Age, Gene, Environment Susceptibility (AGES)-Reykjavik Study cohort of men and women born 1907 to 1935. Coronary artery calcification (CAC), a marker of atherosclerotic burden, was measured with CT. Memory, speed of processing, and executive function composites were calculated from a cognitive test battery. Dementia was assessed in a multistep procedure and diagnosed according to international guidelines. Quantitative data on total intracranial and tissue volumes (total, gray matter volume, white matter volume, and white matter lesion volume), cerebral infarcts, and cerebral microbleeds were obtained with brain MRI. The association of CAC with dementia (n=165 cases) and cognitive function in nondemented subjects (n=4085), and separately with MRI outcomes, was examined in multivariate models adjusting for demographic and vascular risk factors. Analyses tested whether brain structure mediated the associations of CAC to cognitive function.
resultsSubjects with higher CAC were more likely to have dementia and lower cognitive scores, more likely to have lower white matter volume, gray matter volume, and total brain tissue, and to have more cerebral infarcts, cerebral microbleeds, and white matter lesions. The relations of cognitive performance and dementia to CAC were significantly attenuated when the models were adjusted for brain lesions and volumes.
conclusionsIn a population-based sample, increasing atherosclerotic load assessed by CAC is associated with poorer cognitive performance and dementia, and these relations are mediated by evidence of brain pathology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.