ArticleJournal of applied physiology (Bethesda, Md. : 1985)2010
Respiratory and Mayer wave-related discharge patterns of raphé and pontine neurons change with vagotomy.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Cardiovascular phenotyping for personalized lifestyle treatments of chronic abdominal pain in Irritable Bowel Syndrome: A randomized pilot study.Neurogastroenterology and motility · 2019Trial
- Dorsal and median raphe neuronal firing dynamics characterized by nonlinear measures.PLoS computational biology · 2024Article
- Central Autonomic Network Regions and Hypertension: Unveiling Sympathetic Activation and Genetic Therapeutic Perspectives.Biology · 2023Article
- fMRI studies evaluating central respiratory control in humans.Frontiers in neural circuits · 2022Review
- Blood pressure drives multispectral tuning of inspiration via a linked-loop neural network.Journal of neurophysiology · 2020Article
- Traube-Hering waves are formed by interaction of respiratory sinus arrhythmia and pulse pressure modulation in healthy men.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Spinal genesis of Mayer waves.Neural regeneration research · 2020Review
- Relationship between cardiorespiratory phase coherence during hypoxia and genetic polymorphism in humans.The Journal of physiology · 2020Article
- A Hierarchy of Autonomous Systems for Vocal Production.Trends in neurosciences · 2020Review
- Mechanisms Contributing to the Generation of Mayer Waves.Frontiers in neuroscience · 2020Article
- Low-Frequency Oscillations in Cardiac Sympathetic Neuronal Activity.Frontiers in physiology · 2020Review
- Article
- Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.Physiology (Bethesda, Md.) · 2018Review
- Carotid chemoreceptors tune breathing via multipath routing: reticular chain and loop operations supported by parallel spike train correlations.Journal of neurophysiology · 2018Article
- The Role of Failing Autonomic Nervous System on Life-Threatening Idiopathic Systemic Capillary Leak Syndrome.Frontiers in medicine · 2018Article
- Central Respiration and Mechanical Ventilation in the Gating of Swallow With Breathing.Frontiers in physiology · 2018Article
- Baroreflex mechanisms in Irritable Bowel Syndrome: Part I. Traditional indices.Physiology & behavior · 2016Article
- Functional connectivity in raphé-pontomedullary circuits supports active suppression of breathing during hypocapnic apnea.Journal of neurophysiology · 2015Article
- Peripheral chemoreceptors tune inspiratory drive via tonic expiratory neuron hubs in the medullary ventral respiratory column network.Journal of neurophysiology · 2015Article
- Change in network connectivity during fictive-gasping generation in hypoxia: prevention by a metabolic intermediate.Frontiers in physiology · 2014Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Previous models have attributed changes in respiratory modulation of pontine neurons after vagotomy to a loss of pulmonary stretch receptor "gating" of an efference copy of inspiratory drive. Recently, our group confirmed that pontine neurons change firing patterns and become more respiratory modulated after vagotomy, although average peak and mean firing rates of the sample did not increase (Dick et al., J Physiol 586: 4265-4282, 2008). Because raphé neurons are also elements of the brain stem respiratory network, we tested the hypotheses that after vagotomy raphé neurons have increased respiratory modulation and that alterations in their firing patterns are similar to those seen for pontine neurons during withheld lung inflation. Raphé and pontine neurons were recorded simultaneously before and after vagotomy in decerebrated cats. Before vagotomy, 14% of 95 raphé neurons had increased activity during single respiratory cycles prolonged by withholding lung inflation; 13% exhibited decreased activity. After vagotomy, the average index of respiratory modulation (eta(2)) increased (0.05 +/- 0.10 to 0.12 +/- 0.18 SD; Student's paired t-test, P < 0.01). Time series and frequency domain analyses identified pontine and raphé neuron firing rate modulations with a 0.1-Hz rhythm coherent with blood pressure Mayer waves. These "Mayer wave-related oscillations" (MWROs) were coupled with central respiratory drive and became synchronized with the central respiratory rhythm after vagotomy (7 of 10 animals). Cross-correlation analysis identified functional connectivity in 52 of 360 pairs of neurons with MWROs. Collectively, the results suggest that a distributed network participates in the generation of MWROs and in the coordination of respiratory and vasomotor rhythms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.