Evidence map›Paper›PMID 20360336›Full record

ArticleAJNR. American journal of neuroradiology2010

Role of CT angiographic plaque morphologic characteristics in addition to stenosis in predicting the symptomatic side in carotid artery disease.

M Eesa, M D Hill, A Al-Khathaami, M Al-Zawahmah, P Sharma, B K Menon, S Tymchuk, A M Demchuk, Mayank Goyal

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PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  6. Many strokes from a single non-stenosing plaque: from the last event a light to the first one?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

M EesaDepartment of Radiology, University of Calgary, Calgary, Alberta, Canada.
M D Hill
A Al-Khathaami
M Al-Zawahmah
P Sharma
B K Menon
S Tymchuk
A M Demchuk
Mayank Goyal
University of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAtherosclerotic disease of the carotid artery is an important cause of ischemic stroke. We evaluated carotid plaque morphologic features by using CTA in addition to stenosis in the setting of symptomatic hemispheric TIA/stroke to identify factors that may predict plaque activity. MATERIALS AND

methodsSix hundred seventy-three patients (408 men; ages, 18-91 years; mean, 65.8 +/- 15.2 years) presenting with hemispheric ischemic symptoms and having a CTA that included imaging of both carotid arteries within 24 hours were studied. Scans were interpreted for morphologic features, such as plaque length and width, attenuation, shape, surface, presence and degree of calcification, and ILT in addition to stenosis.

resultsUnivariable analysis showed that carotid occlusions (P = .01, OR = 5.27), high-grade stenosis (70%-99%) (P = .06, OR = 1.8), and the presence of ILT (P = .01, OR = 4.33) were highly predictive of the symptomatic side. Smooth plaque (P = .01, OR = 0.73) and extensive calcification (P = .03, OR = 0.72) were more commonly associated with the asymptomatic side. There was no correlation between plaque hypoattenuation (P = .7, OR = 1.06) or ulcerated plaque (P = .74, OR = 0.955) in predicting the symptomatic side. In a multivariable logistic regression model, the presence of ILT was still found to be significantly associated with the symptomatic side (P = .048, OR = 3.1) and the presence of extensive calcification, with the asymptomatic carotid artery (P = .047, OR = 0.69).

conclusionsIn addition to higher stenosis grades, the presence of ILT is highly predictive of the symptomatic side in carotid disease. Smooth plaque and extensive calcification seem to afford a protective effect. This information may be useful in radiologic risk stratification in carotid disease in addition to the current evidence available based on stenosis criteria alone.

Indexed as

AdolescentAdultAgedAged, 80 and overCarotid StenosisCerebral AngiographyFemaleHumansIschemic Attack, TransientMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsRetrospective StudiesRisk FactorsStroke

Identifiers

PMID20360336
PMCPMC7965448
OpenAlexW2067447797

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.