ArticleInternational journal of epidemiology2010
Does depression predict coronary heart disease and cerebrovascular disease equally well? The Health and Social Support Prospective Cohort Study.
Article in International journal of epidemiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Association between depression and stroke risk in adults: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Antidepressant use and risk of coronary heart disease: meta-analysis of observational studies.British journal of clinical pharmacology · 2014Pooled it
- Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review.JAMA · 2011Pooled it
- Blueprint 2: A self-directed mobile adaptive coping skills intervention to improve psychological distress symptoms among cardiorespiratory failure survivors study protocol.Contemporary clinical trials · 2026Article
- Major depressive disorder (MDD) and the risks of mortality and hospitalization in the UK Biobank.BMC psychiatry · 2026Article
- Depression and incidence of inflammation-related physical health conditions: a cohort study in UK Biobank.BMC psychiatry · 2025Article
- Comparison of Risk of Stroke in Patients With and Without Depression: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Depression increased risk of coronary heart disease: A meta-analysis of prospective cohort studies.Frontiers in cardiovascular medicine · 2022Article
- Role of depressive symptoms in cardiometabolic diseases and subsequent transitions to all-cause mortality: an application of multistate models in a prospective cohort study.Stroke and vascular neurology · 2021Article
- Association of Symptoms of Depression With Cardiovascular Disease and Mortality in Low-, Middle-, and High-Income Countries.JAMA psychiatry · 2020Article
- Association of Major Depressive Episodes With Stroke Risk in a Prospective Study of 0.5 Million Chinese Adults.Stroke · 2016Article
- Elucidating the Association Between Depressive Symptoms, Coronary Heart Disease, and Stroke in Black and White Adults: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study.Journal of the American Heart Association · 2016Article
- Inflammatory insults and mental health consequences: does timing matter when it comes to depression?Psychological medicine · 2016Article
- Article
- Exploring the risk-factor association between depression and incident stroke: a systematic review and meta-analysis.Neuropsychiatric disease and treatment · 2015Article
- Depression and the risk of coronary heart disease: a meta-analysis of prospective cohort studies.BMC psychiatry · 2014Review
- An exploration of the dynamic longitudinal relationship between mental health and alcohol consumption: a prospective cohort study.BMC medicine · 2014Article
- Risk factors for cerebrovascular disease mortality among the elderly in Beijing: a competing risk analysis.PloS one · 2014Article
- Clinical depression, antidepressant use and risk of future cardiovascular disease.European journal of epidemiology · 2013Article
- Usefulness of a single-item measure of depression to predict mortality: the GAZEL prospective cohort study.European journal of public health · 2012Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe relationship between depression and cerebrovascular disease (CBVD) continues to be debated although little research has compared the predictive power of depression for coronary heart disease (CHD) with that for CBVD within the same population. This study aimed to compare the importance of depression for CHD and CBVD within the same population of adults free of apparent cardiovascular disease.
methodsA random sample of 23,282 adults (9507 men, 13,775 women) aged 20-54 years were followed up for 7 years. Fatal and first non-fatal CHD and CBVD events were documented by linkage to the National-hospital-discharge and mortality registers.
resultsSex-age-education-adjusted hazard ratio (HR) for CHD was 1.66 [95% confidence interval (CI) 1.24-2.24] for participants with mild to severe depressive symptoms, i.e. those scoring > or =10 on the 21-item Beck Depression Inventory, and 2.04 (1.27-3.27) for those who filled antidepressant prescriptions compared with those without depression markers in 1998, i.e. at study baseline. For CBVD, the corresponding HRs were 1.01 (0.67-1.53) and 1.77 (0.95-3.29). After adjustment for behavioural and biological risk factors these associations were reduced but remained evident for CHD, the adjusted HRs being 1.47 (1.08-1.99) and 1.72 (1.06-2.77). For CBVD, the corresponding multivariable adjusted HRs were 0.87 (0.57-1.32) and 1.52 (0.81-2.84).
conclusionsSelf-reported depression using a standardized questionnaire and clinical markers of mild to severe depression were associated with an increased risk for CHD. There was no clear evidence that depression is a risk factor for CBVD, but this needs further confirmation.
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