ArticleThe American journal of psychiatry2010
Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder.
Article in The American journal of psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.Molecular psychiatry · 2012Pooled it
- Characterization of a large group of individuals with huntington disease and their relatives enrolled in the COHORT study.PloS one · 2012Trial
- Huntingtin CAG repeat size variations below the Huntington's disease threshold: associations with depression, anxiety and basal ganglia structure.European journal of human genetics : EJHG · 2025Article
- Significant underascertainment in Huntington's disease.Brain communications · 2025Article
- The pathobiology of depression in Huntington's disease: an unresolved puzzle.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Article
- The Prevalence of Psychotic Symptoms, Violent Ideation, and Disruptive Behavior in a Population With SARS-CoV-2 Infection: Preliminary Study.JMIR formative research · 2022Article
- Tandem repeats mediating genetic plasticity in health and disease.Nature reviews. Genetics · 2018Review
- Population-specific genetic modification of Huntington's disease in Venezuela.PLoS genetics · 2018Article
- Article
- Huntingtin gene repeat size variations affect risk of lifetime depression.Translational psychiatry · 2017Review
- Haplotype-based stratification of Huntington's disease.European journal of human genetics : EJHG · 2017Article
- Large normal-range TBP and ATXN7 CAG repeat lengths are associated with increased lifetime risk of depression.Translational psychiatry · 2017Article
- Retinal Nerve Fiber Layer Thickness Measurement by Spectral-Domain Optical Coherence Tomography in Patients with Major Depressive Disorder.Noro psikiyatri arsivi · 2017Article
- The HTT CAG-Expansion Mutation Determines Age at Death but Not Disease Duration in Huntington Disease.American journal of human genetics · 2016Observational
- The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Review
- Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder.Bipolar disorders · 2015Article
- Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Article
- Edgotype: a fundamental link between genotype and phenotype.Current opinion in genetics & development · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivePresymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington's disease may have higher levels of depressive symptoms than healthy comparison populations. However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established.
methodThis was a case-control genetic association study of HTT CAG allele size in two discovery cohorts of individuals with major depressive disorder and comparison subjects without major depression as well as a replication cohort of individuals with major depression and comparison subjects without major depression.
resultsCAG repeat lengths of 36 or greater were observed in six of 3,054 chromosomes from individuals with major depression, compared with none of 4,155 chromosomes from comparison subjects. In a third cohort, one expanded allele was observed among 1,202 chromosomes in the major depression group, compared with none of 2,678 chromosomes in comparison subjects. No clear pattern of clinical features was shared among individuals with the expanded repeats.
conclusionsIn clinical populations of individuals diagnosed with major depression, approximately 3 in 1,000 carried expanded HTT CAG alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.