ArticleMolecular biology and evolution2010
Constrained intron structures in a microsporidian.
Article in Molecular biology and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Article
- A Putative TRAPα Protein of MicrosporidiaJournal of fungi (Basel, Switzerland) · 2023Article
- Impact of Genome Reduction in Microsporidia.Experientia supplementum (2012) · 2022Article
- Analysis of Fungal Genomes Reveals Commonalities of Intron Gain or Loss and Functions in Intron-Poor Species.Molecular biology and evolution · 2021Article
- Patterns of conservation of spliceosomal intron structures and spliceosome divergence in representatives of the diplomonad and parabasalid lineages.BMC evolutionary biology · 2019Article
- Microsporidian Introns Retained against a Background of Genome Reduction: Characterization of an Unusual Set of Introns.Genome biology and evolution · 2019Article
- Evolution and Diversity of Pre-mRNA Splicing in Highly Reduced Nucleomorph Genomes.Genome biology and evolution · 2018Article
- Comparative genomics of microsporidian genomes reveals a minimal non-coding RNA set and new insights for transcription in minimal eukaryotic genomes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- The Macronuclear Genome of Stentor coeruleus Reveals Tiny Introns in a Giant Cell.Current biology : CB · 2017Article
- Transcriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominis.BMC genomics · 2015Article
- Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes.Nature communications · 2015Article
- Origin of spliceosomal introns and alternative splicing.Cold Spring Harbor perspectives in biology · 2014Article
- Transcriptome analysis of the parasite Encephalitozoon cuniculi: an in-depth examination of pre-mRNA splicing in a reduced eukaryote.BMC genomics · 2013Article
- The genome of Spraguea lophii and the basis of host-microsporidian interactions.PLoS genetics · 2013Article
- Gain and loss of multiple functionally related, horizontally transferred genes in the reduced genomes of two microsporidian parasites.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Annotation of microsporidian genomes using transcriptional signals.Nature communications · 2012Article
- The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.PLoS pathogens · 2012Article
- Diverse forms of RPS9 splicing are part of an evolving autoregulatory circuit.PLoS genetics · 2012Article
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Authors and funding
4 authors.
Funding
Abstract
The 2.9-Mbp genome of the microsporidian Encephalitozoon cuniculi is severely reduced and compacted, possessing only 16 known tiny spliceosomal introns. Based on motif and expression data, intron profiles were constructed to screen the genome. Twenty additional introns were predicted and verified, doubling the previous estimate. We further predict that accurate 3' splice site (3'SS) selection is accomplished via a scanning mechanism with specificity achieved by maintaining a constrained variable length between the branch point motif and 3'SS. Only introns in ribosomal protein genes exhibit positional bias, and we hypothesize that splicing could be regulating expression of these genes. The large set of new introns in non-ribosomal protein genes suggests that current models of intron loss are unlikely sufficient to explain the distribution of introns. Together, these results extend our understanding of the role of intron loss in genome evolution and contribute to a novel model for splice site selection.
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