ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2010
A search for activation of C nociceptors by sympathetic fibers in complex regional pain syndrome.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Functional and molecular diversity of human C-fibers in pain modulation.Current opinion in supportive and palliative care · 2026Review
- Electrophysiological characterization of ectopic spontaneous discharge in axotomized and intact fibers upon nerve transection: a role in spontaneous pain?Pflugers Archiv : European journal of physiology · 2022Review
- Recent updates in the treatment of diabetic polyneuropathy.Faculty reviews · 2022Review
- Article
- End points for sickle cell disease clinical trials: patient-reported outcomes, pain, and the brain.Blood advances · 2019Article
- Complex regional pain syndrome: a focus on the autonomic nervous system.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- How is chronic pain related to sympathetic dysfunction and autonomic dysreflexia following spinal cord injury?Autonomic neuroscience : basic & clinical · 2018Review
- New Concepts in Complex Regional Pain Syndrome.Hand clinics · 2016Review
- Mechanism-based treatment in complex regional pain syndromes.Nature reviews. Neurology · 2014Review
- Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part I).Medical science monitor : international medical journal of experimental and clinical research · 2014Review
- Activity-dependent slowing properties of an unmyelinated low threshold mechanoreceptor in human hairy skin.Neuroscience letters · 2011Article
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4 authors.
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Abstract
objectiveAlthough the term 'reflex sympathetic dystrophy' has been replaced by 'complex regional pain syndrome' (CRPS) type I, there remains a widespread presumption that the sympathetic nervous system is actively involved in mediating chronic neuropathic pain ["sympathetically maintained pain" (SMP)], even in the absence of detectable neuropathophysiology.
methodsWe have used microneurography to evaluate possible electrophysiological interactions in 24 patients diagnosed with CRPS I (n=13), or CRPS II (n=11) by simultaneously recording from single identified sympathetic efferent fibers and C nociceptors, while provoking sympathetic neural discharges in cutaneous nerves.
resultsWe assessed potential effects of sympathetic activity upon 35 polymodal nociceptors and 19 mechano-insensitive nociceptors, recorded in CRPS I (26 nociceptors) and CRPS II patients (28 nociceptors). No evidence of activation of nociceptors related to sympathetic discharge was found, although nociceptors in six CRPS II patients exhibited unrelated spontaneous pathological nerve impulse activity.
conclusionsWe conclude that activation of nociceptors by sympathetic efferent discharges is not a cardinal pathogenic event in either CRPS I or CRPS II patients. SIGNIFICANCE: This study shows that sympathetic-nociceptor interactions, if they exist in patients communicating chronic neuropathic pain, must be the exception.
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