ArticleNeurobiology of aging2012
Functional correlates of instrumental activities of daily living in mild Alzheimer's disease.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Growth-Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study.Health science reports · 2025Article
- Subjective Cognitive Decline in Community-Dwelling Older Adults With Objectively Normal Cognition: Mediation by Depression and Instrumental Activities of Daily Living.Psychiatry investigation · 2024Article
- Brain atrophy trajectories predict differential functional performance in Alzheimer's disease: Moderations with apolipoprotein E and sex.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Functional reserve: The residual variance in instrumental activities of daily living not explained by brain structure, cognition, and demographics.Neuropsychology · 2021Article
- Regional Hypoperfusion Predicts Decline in Everyday Functioning at Three-Year Follow-Up in Older Adults without Dementia.Journal of Alzheimer's disease : JAD · 2020Article
- Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease.Alzheimer's research & therapy · 2019Article
- Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia.Journal of Alzheimer's disease : JAD · 2019Article
- Selecting the most relevant brain regions to discriminate Alzheimer's disease patients from healthy controls using multiple kernel learning: A comparison across functional and structural imaging modalities and atlases.NeuroImage. Clinical · 2018Article
- The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2015Article
- Longitudinal Analysis of Physical Performance, Functional Status, Physical Activity, and Mood in Relation to Executive Function in Older Adults Who Fall.Journal of the American Geriatrics Society · 2015Article
- Functional Activities Questionnaire Items that Best Discriminate and Predict Progression from Clinically Normal to Mild Cognitive Impairment.Current Alzheimer research · 2015Observational
- Assessment of functional change and cognitive correlates in the progression from healthy cognitive aging to dementia.Neuropsychology · 2014Article
- Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum.Journal of Alzheimer's disease : JAD · 2014Article
- Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment.Current Alzheimer research · 2014Article
- Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum.Journal of Alzheimer's disease : JAD · 2014Article
- Everyday cognition in older adults: associations with neuropsychological performance and structural brain imaging.Journal of the International Neuropsychological Society : JINS · 2013Article
- Association between cerebral metabolism and Rey-Osterrieth Complex Figure Test performance in Alzheimer's disease.Journal of clinical and experimental neuropsychology · 2013Article
- OPTIMIZING DIAGNOSIS AND MANANGEMENT IN MILD-TO-MODERATE ALZHEIMER'S DISEASE.Neurodegenerative disease management · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Instrumental activities of daily living (IADL) includes the integration of task-initiation, -planning, and -performance. Little is known on the cerebral perfusion correlates of these subcomponents of IADL in Alzheimer's disease (AD). In 121 AD patients, cerebral perfusion, using single-photon emission computed tomography, in 13 bilateral regions of interest (ROI) and the perfusion correlates of IADL subcomponents, rated on the Disability Assessment in Dementia scale, were explored. Significant correlations were observed between IADL initiation and multiple bilateral prefrontal-striatal-anterior cingulate ROI (p < 0.01), IADL planning and right occipital ROI (p < 0.05), and IADL performance and right parietal ROI (p < 0.05). Multiple regression, accounting for age, cognitive impairment, and depression severity, revealed significant relationship between right basal ganglia perfusion and IADL-initiation (R = 0.6, R(2) = 0.39, F(4,117) = 17.8, SE = 1.56; p < 0.001) and right occipital perfusion and IADL-planning (R = 0.6, R(2) = 0.34, F(4,117) = 19.5, SE = 1.47; p < 0.001). In AD, perfusion correlates of these subcomponents may be linked to the heterogenous cognitive processes involved in IADL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.